IL-7 is a Key Driver Cytokine in Spondyloarthritis?

Rafaela Silva Guimarães Gonçalves, Angela Luzia Branco Pinto Duarte
Author Information
  1. Rafaela Silva Guimarães Gonçalves: Hospital das Clínicas de Pernambuco, Brazil. ORCID
  2. Angela Luzia Branco Pinto Duarte: Hospital das Clínicas de Pernambuco, Brazil. ORCID

Abstract

The rationale for a type 17 signature in the pathogenesis of spondyloarthritis (SpA) has been increasing and being ratified in studies recently. IL-7 is a cytokine whose ability to stimulate IL-17 production in both innate and adaptive immunity cells has made it a promising target not only for a better understanding of the disease as well as an important potential therapeutic target in patients with SpA.

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MeSH Term

Adaptive Immunity
Animals
Cytokines
Disease Susceptibility
Fibrosis
Humans
Immunity, Innate
Interleukin-7
Protein Binding
Receptors, Cytokine
Signal Transduction
Spondylarthritis
T-Lymphocyte Subsets

Chemicals

Cytokines
Interleukin-7
Receptors, Cytokine

Word Cloud

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