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Current opinion in biotechnology
08, 2019;58 192-201.

Systems engineering the organ preservation process for transplantation.

Reinier J de Vries, Martin Yarmush, Korkut Uygun
Author Information
  1. Reinier J de Vries: Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Shriners Hospital for Children, Boston, MA, USA; Department of Surgery, University of Amsterdam, Amsterdam, The Netherlands.
  2. Martin Yarmush: Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Shriners Hospital for Children, Boston, MA, USA; Department of Biomedical Engineering, Rutgers University, New Brunswick, NJ, USA.
  3. Korkut Uygun: Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Shriners Hospital for Children, Boston, MA, USA. Electronic address: kuygun@mgh.harvard.edu.
PMID: 31280087 DOI: 10.1016/j.copbio.2019.05.015

Abstract

Improving organ preservation and extending the preservation time would have game-changing effects on the current practice of organ transplantation. Machine perfusion has emerged as an improved preservation technology to expand the donor pool, assess graft viability and ensure adequate graft function. However, its efficacy in extending the preservation time is limited. Subzero organ preservation does hold the promise to significantly extend the preservation time and recent advances in cryobiology bring it closer to clinical translation. In this review, we aim to broaden the perspective in the field from a focus on these individual technologies to that of a systems engineering. This would enable the creation of a preservation process that integrates the benefits of machine perfusion with those of subzero preservation, with the ultimate goal to provide on demand availability of donor organs through organ banking.

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Grants

  1. R01 DK096075/NIDDK NIH HHS
  2. R01 DK107875/NIDDK NIH HHS
  3. R01 DK114506/NIDDK NIH HHS

MeSH Term

Humans
Organ Preservation
Perfusion
Tissue Donors
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review
Article has an altmetric score of 3

Word Cloud

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