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Environmental science and pollution research international
Sep, 2019;26 (25): 26090-26101.

Global DNA methylation changes in rock pigeon (Columba livia) as a sentinel species due to polycyclic aromatic hydrocarbons exposure in Tehran (Iran) as a megacity.

Sahel Pakzad Toochaei, Seyed Mahmoud Ghasempouri, Alireza Riyahi Bakhtiari, Saber Khodabandeh
Author Information
  1. Sahel Pakzad Toochaei: Hamoun International Wetland Research Institute, University of Zabol, 98615-538, Zabol, Iran.
  2. Seyed Mahmoud Ghasempouri: Department of Environmental Science, Faculty of Natural Resources, Tarbiat Modares University, P.O. Box 46414-356, Noor, Iran. ghasempm@modares.ac.ir. ORCID
  3. Alireza Riyahi Bakhtiari: Department of Environmental Science, Faculty of Natural Resources, Tarbiat Modares University, P.O. Box 46414-356, Noor, Iran.
  4. Saber Khodabandeh: Department of Marine Biology, Faculty of Marine Sciences, Tarbiat Modares University, P.O.Box 46414-356, Noor, Iran.
PMID: 31280440 DOI: 10.1007/s11356-019-05642-9

Abstract

Global DNA methylation, as an epigenetic modifications, can be a promising genomic marker for monitoring the contaminants and predicting their adverse health effects. The study aims to assess the effects of 16 PAH concentration on the altered DNA methylation levels in the kidney and liver of rock pigeon (Columba livia), as a sentinel species, from Tehran megacity as well as 40 days benzo(a)pyrene in vitro exposure: (0.1, 2.5, 5, 7.5, and 10 mg kg bw). Data indicated that the total LMW-PAH (low molecular weight PAHs) group (120.22, 121.34, 103.69, and 128.79 ng g dw in liver, kidney, skin, and muscle, respectively) in the Tehran samples have higher levels than the other PAHs groups. In addition, the DNA methylation level had negative relation with the total amount of PAHs in liver and kidney. A comparatively higher global DNA hypomethylation (by 8.65% in liver and 3.76% in kidney) was observed in birds exposed to B(a)P. Our results lead us to suggest that DNA hypomethylation in liver and kidney associated with the B(a)P may be useful biomarker discovery (more than the amount of PAH concentration in different tissues of C. livia) in urban areas. In conclusion, based on the overall results assessed, DNA methylation changes in pigeon may show a new target pathway for evaluation of environmental health.

Keywords

Benzo[a]pyrene Global DNA methylation Megacity PAHs Rock pigeon Sentinel species

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Grants

  1. 152_D_2154:95/06/07./Tarbiat Modares University

MeSH Term

Animals
Benzo(a)pyrene
Columbidae
DNA Methylation
Environmental Monitoring
Iran
Polycyclic Aromatic Hydrocarbons
Sentinel Species

Chemicals

Polycyclic Aromatic Hydrocarbons
Benzo(a)pyrene
Journal Article
Article has an altmetric score of 2

Word Cloud

Created with Highcharts 10.0.0DNAmethylationkidneyliverpigeonPAHsGloballiviaspeciesTehran5healtheffectsPAHconcentrationlevelsrockColumbasentinelmegacitytotalhigheramounthypomethylationBPresultsmaychangesepigeneticmodificationscanpromisinggenomicmarkermonitoringcontaminantspredictingadversestudyaimsassess16alteredwell40 daysbenzopyrenevitroexposure:012710 mg kgbwDataindicatedLMW-PAHlowmolecularweightgroup12022121341036912879 ng gdwskinmusclerespectivelysamplesgroupsadditionlevelnegativerelationcomparativelyglobal865%376%observedbirdsexposedleadussuggestassociatedusefulbiomarkerdiscoverydifferenttissuesCurbanareasconclusionbasedoverallassessedshownewtargetpathwayevaluationenvironmentalduepolycyclicaromatichydrocarbonsexposureIranBenzo[a]pyreneMegacityRockSentinel

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