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07 17, 2019;11 (7):

Wild Rats, Laboratory Rats, Pet Rats: Global Seoul Hantavirus Disease Revisited.

Jan Clement, James W LeDuc, Graham Lloyd, Jean-Marc Reynes, Lorraine McElhinney, Marc Van Ranst, Ho-Wang Lee
Author Information
  1. Jan Clement: National Reference Centre for Hantavirus Infections, Laboratory of Clinical and Epidemiological Virology, University Hospital of Leuven, 3000 Leuven, Belgium. jan.clement@uzleuven.be.
  2. James W LeDuc: Galveston National Laboratory, University of Texas Medical Branch, Galveston, TX 77555-0610, USA.
  3. Graham Lloyd: Laboratory for Public Health England, Porton Down, Wiltshire SP4 OJG, UK.
  4. Jean-Marc Reynes: National Reference Centre for Hantaviruses, Unité Environnement et Risques Infectieux, Institut Pasteur, 75724 Paris CEDEX 15, France.
  5. Lorraine McElhinney: Wildlife Zoonoses and Vector Borne Diseases Group, Animal and Plant Health Agency, Surrey KT15 3NB, UK.
  6. Marc Van Ranst: National Reference Centre for Hantavirus Infections, Laboratory of Clinical and Epidemiological Virology, University Hospital of Leuven, 3000 Leuven, Belgium.
  7. Ho-Wang Lee: WHO Collaborating Centre for Hemorrhagic Fever with renal Syndrome, National Academy of Science, Seoul 06579, Korea.
PMID: 31319534 DOI: 10.3390/v11070652

Abstract

Recent reports from Europe and the USA described Seoul orthohantavirus infection in pet rats and their breeders/owners, suggesting the potential emergence of a "new" public health problem. Wild and laboratory rat-induced Seoul infections have, however, been described since the early eighties, due to the omnipresence of the rodent reservoir, the brown rat . Recent studies showed no fundamental differences between the pathogenicity and phylogeny of pet rat-induced Seoul orthohantaviruses and their formerly described wild or laboratory rat counterparts. The paucity of diagnosed Seoul virus-induced disease in the West is in striking contrast to the thousands of cases recorded since the 1980s in the Far East, particularly in China. This review of four continents (Asia, Europe, America, and Africa) puts this "emerging infection" into a historical perspective, concluding there is an urgent need for greater medical awareness of Seoul virus-induced human pathology in many parts of the world Given the mostly milder and atypical clinical presentation, sometimes even with preserved normal kidney function, the importance of simple but repeated urine examination is stressed, since initial but transient proteinuria and microhematuria are rarely lacking.

Keywords

Seoul virus (SEOV) acute kidney injury (AKI) brown rat hantavirus hantavirus cardio-pulmonary syndrome (HCPS) hantavirus disease hemorrhagic fever with renal syndrome (HFRS) laboratory rat pet rat wild rat

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Grants

  1. UC7 AI094660/NIAID NIH HHS

MeSH Term

Animals
Animals, Laboratory
Animals, Wild
Communicable Diseases, Emerging
Geography, Medical
Global Health
Hemorrhagic Fever with Renal Syndrome
Pets
Rats
Seoul virus
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 4

Word Cloud

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