Quantification of CYFRA 21-1 and a CYFRA 21-1-anti-CYFRA 21-1 autoantibody immune complex for detection of early stage lung cancer.

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Keum-Soo Song, Satish Balasaheb Nimse, Shrikant Dashrath Warkad, Ae-Chin Oh, Taisun Kim, Young Jun Hong

Author Information

Keum-Soo Song: Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon, 24252, South Korea. tskim@hallym.ac.kr.

PMID: 31328750 DOI: 10.1039/c9cc03620b

Population-based screening of stage 0-I lung cancer is crucial to save lives. In this article, we describe the development of a method for the detection of a CYFRA 21-1-autoantibody complex and CYFRA 21-1 in plasma samples. The CIC/CYFRA 21-1 ratio allows the detection of stage I-IV lung cancer with 76.0% sensitivity and 87.5% specificity.

Adult

Aged

Animals

Antibodies, Monoclonal, Murine-Derived

Antigen-Antibody Complex

Antigens, Neoplasm

Autoantibodies

Biomarkers, Tumor

Carbocyanines

DNA

Female

Fluorescent Dyes

Goats

Humans

Immunoassay

Immunoglobulin G

Keratin-19

Limit of Detection

Lung Neoplasms

Male

Mice

Middle Aged

Nucleic Acid Hybridization

Sensitivity and Specificity

Antibodies, Monoclonal, Murine-Derived

Antigen-Antibody Complex

Antigens, Neoplasm

Autoantibodies

Biomarkers, Tumor

Carbocyanines

Fluorescent Dyes

Immunoglobulin G

Keratin-19

antigen CYFRA21.1

cyanine dye 5

DNA

Journal Article

Synergistic Assembly of 1DZnO and Anti-CYFRA 21-1: A Physicochemical Approach to Optical Biosensing.The Usefulness of the Ratio of Antigen-Autoantibody Immune Complexes to Their Free Antigens in the Diagnosis of Non-Small Cell Lung Cancer.Enhanced Lung Cancer Detection Using a Combined Ratio of Antigen-Autoantibody Immune Complexes against CYFRA 21-1 and p53.9G Test Cancer/Lung: A Desirable Companion to LDCT for Lung Cancer Screening.Detection and Quantification of Tp53 and p53-Anti-p53 Autoantibody Immune Complex: Promising Biomarkers in Early Stage Lung Cancer Diagnosis.Assessing the 9G Technology Blood Test for Predicting Lung Cancer in Patients with CT-Detected Lung Nodules: A Multicenter Clinical Trial.Discovering Panel of Autoantibodies for Early Detection of Lung Cancer Based on Focused Protein Array.

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