The novel cannabinoid CB receptor agonist AM11101 increases food intake in female rats.
Sean B Ogden, Michael S Malamas, Alexandros Makriyannis, Lisa A Eckel
Author Information
Sean B Ogden: Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, Florida. ORCID
Michael S Malamas: Center for Drug Discovery, Departments of Chemistry, Chemical Biology, and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts.
Alexandros Makriyannis: Center for Drug Discovery, Departments of Chemistry, Chemical Biology, and Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts. ORCID
Lisa A Eckel: Program in Neuroscience, Department of Psychology, Florida State University, Tallahassee, Florida. ORCID
BACKGROUND AND PURPOSE: Δ -tetrahydrocannabinol (THC) acts via cannabinoid CB receptors to increase feeding. Here, we assessed the orexigenic effect of AM11101, a novel CB receptor agonist designed to have a more favourable pharmacodynamic profile than THC. EXPERIMENTAL APPROACH: The acute, orexigenic effects of AM11101 and THC were compared in female rats. Food intake and meal patterns were also examined following once daily treatment with AM11101 and THC for 7 days. KEY RESULTS: AM11101 (0.01-0.1 mg·kg ) increased food intake during the first hour following both acute and chronic treatments in pre-fed and freely feeding animals. This orexigenic effect persisted for up to 4 hr, with no compensatory decrease in feeding during the subsequent 4-22 hr. THC (1 mg·kg ) increased 1-hr food intake in pre-fed animals, but was less reliable than AM11101 in increasing 1-hr food intake in freely feeding animals following both acute and chronic administration. The orexigenic effect of both compounds was due to an increase in meal size, not meal number. CONCLUSIONS AND IMPLICATIONS: Our study provides the first demonstration that AM11101 increases short-term food intake via a selective increase in meal size. AM11101 promotes a more reliable orexigenic effect than THC in freely feeding animals, with no subsequent compensatory decrease in feeding. AM11101 may offer a greater efficacy than THC and its congeners in stimulating food intake in underweight clinical populations.
