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Physiology (Bethesda, Md.)
09 01, 2019;34 (5): 365-375.

Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders.

Jason W Adams, Fernanda R Cugola, Alysson R Muotri
Author Information
  1. Jason W Adams: Department of Pediatrics/Rady Children's Hospital San Diego, School of Medicine, University of California San Diego, San Diego, California.
  2. Fernanda R Cugola: Department of Pediatrics/Rady Children's Hospital San Diego, School of Medicine, University of California San Diego, San Diego, California.
  3. Alysson R Muotri: Department of Pediatrics/Rady Children's Hospital San Diego, School of Medicine, University of California San Diego, San Diego, California.
PMID: 31389776 DOI: 10.1152/physiol.00005.2019

Abstract

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development, thus offering an innovative tool by which to model human neurodevelopmental disease. We review here how brain organoids have been used to study neurodevelopmental disease and consider their potential for both technological advancement and therapeutic development.

Keywords

disease modeling neurodevelopmental disease organoids stem cells

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Grants

  1. R01 MH108528/NIMH NIH HHS
  2. R01 MH109885/NIMH NIH HHS
  3. R56 MH109587/NIMH NIH HHS
  4. T32 GM007198/NIGMS NIH HHS
  5. R01 MH100175/NIMH NIH HHS
  6. R01 MH094753/NIMH NIH HHS

MeSH Term

Animals
Brain
Humans
Models, Biological
Neurodevelopmental Disorders
Organoids
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 3

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Created with Highcharts 10.0.0diseaseorganoidsneurodevelopmentalBrainhumanbraindevelopmentrecapitulatevitrospecificstagesvivothusofferinginnovativetoolmodelreviewusedstudyconsiderpotentialtechnologicaladvancementtherapeuticOrganoidsToolsModelingHumanNeurodevelopmentalDisordersmodelingstemcells

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