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Dermatology and therapy
Dec, 2019;9 (4): 807-814.

Revisiting Imiquimod for Treatment of Folliculotropic Mycosis Fungoides: A Case Report and Review of the Literature.

Doaa Shalabi, Nish Vadalia, Neda Nikbakht
Author Information
  1. Doaa Shalabi: Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
  2. Nish Vadalia: Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
  3. Neda Nikbakht: Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA. neda.nikbakht@jefferson.edu.
PMID: 31407190 DOI: 10.1007/s13555-019-00317-2

Abstract

Folliculotropic mycosis fungoides (FMF) is an aggressive variant of mycosis fungoides (MF) characterized by infiltration of the hair follicle epithelium by neoplastic T cells. FMF demonstrates poor response rates to standard skin-directed therapies such as phototherapy and topical corticosteroids. Imiquimod, an immunomodulatory agent that stimulates the antitumor immune response, has been used successfully in treatment of early-stage MF. We report a 21-year-old patient with unilesional FMF who achieved clinical remission with imiquimod application. This case highlights a potential for use of imiquimod as a treatment option for patients with FMF and limited skin involvement.

Keywords

Folliculotropic mycosis fungoides Imiquimod Toll-like receptor 7 agonist

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