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Aug 12, 2019;11 (8):

Biological Significance of Tumor Heterogeneity in Esophageal Squamous Cell Carcinoma.

Lehang Lin, De-Chen Lin
Author Information
  1. Lehang Lin: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen University, Guangzhou 510120, China.
  2. De-Chen Lin: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen University, Guangzhou 510120, China. lindch5@mail.sysu.edu.cn.
PMID: 31409002 DOI: 10.3390/cancers11081156

Abstract

Esophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy, with hitherto dismal clinical outcome. Genomic analyses of patient samples reveal a complex heterogeneous landscape for ESCC, which presents in both intertumor and intratumor forms, manifests at both genomic and epigenomic levels, and contributes significantly to tumor evolution, drug resistance, and metastasis. Here, we review the important molecular characteristics underlying ESCC heterogeneity, with an emphasis on genomic aberrations and their functional contribution to cancer evolutionary trajectories. We further discuss how novel experimental tools, including single-cell sequencing and three-dimensional organoids, may advance our understanding of tumor heterogeneity. Lastly, we suggest that deciphering the mechanisms governing tumor heterogeneity holds the potential to developing precision therapeutics for ESCC patients.

Keywords

esophageal squamous cell carcinoma precision medicine tumor evolution tumor heterogeneity

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Grants

  1. 81672786, 81872306, 81802692/National Natural Science Foundation of China
  2. 2018M640867, 2019T120774/China Postdoctoral Science Foundation
  3. 2017B030314026/Guangdong Science and Technology Department
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