MDSCs: friend or foe in systemic lupus erythematosus.
Jianjian Ji, Pengfei Li, Cunsi Shen, Huan Dou, Tingting Wang, Liyun Shi, Yayi Hou
Author Information
- Jianjian Ji: Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, 210023, Nanjing, China.
- Pengfei Li: Department of Clinical Laboratory, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China. ORCID
- Cunsi Shen: Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, 210023, Nanjing, China.
- Huan Dou: The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology and Hospital of Stomatology, Medical School, Nanjing University, Nanjing, China.
- Tingting Wang: The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology and Hospital of Stomatology, Medical School, Nanjing University, Nanjing, China.
- Liyun Shi: Key Laboratory of Inflammation and Immunoregulation, School of Medical and Life Science, Nanjing University of Chinese Medicine, 210046, Nanjing, China. shi_liyun@msn.com.
- Yayi Hou: The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology and Hospital of Stomatology, Medical School, Nanjing University, Nanjing, China. yayihou@nju.edu.cn.
No abstract text available.
- Lu, Y. et al. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1alpha-dependent glycolysis. Cell Mol. Immunol. 15, 618–629 (2018).
[DOI: 10.1038/cmi.2017.5]
- Veglia, F., Perego, M. & Gabrilovich, D. Myeloid-derived suppressor cells coming of age. Nat. Immunol. 19, 108–119 (2018).
[DOI: 10.1038/s41590-017-0022-x]
- Wu, H. et al. Arginase-1-dependent promotion of TH17 differentiation and disease progression by MDSCs in systemic lupus erythematosus. Sci. Transl. Med. 8, 331ra40 (2016).
[DOI: 10.1126/scitranslmed.aae0482]
- Ji, J. et al. Myeloid-derived suppressor cells contribute to systemic lupus erythaematosus by regulating differentiation of Th17 cells and Tregs. Clin. Sci. 130, 1453–1467 (2016).
[DOI: 10.1042/CS20160311]
- Trigunaite, A. et al. Gr-1(high) CD11b+ cells suppress B cell differentiation and lupus-like disease in lupus-prone male mice. Arthritis Rheumatol. 65, 2392–2402 (2013).
[DOI: 10.1002/art.38048]
- Park, M. J. et al. Myeloid-derived suppressor cells induce the expansion of regulatory B cells and ameliorate autoimmunity in the sanroque mouse model of systemic lupus erythematosus. Arthritis Rheumatol. 68, 2717–2727 (2016).
[DOI: 10.1002/art.39767]
- Lourenco, E. V., Wong, M., Hahn, B. H., Palma-Diaz, M. F. & Skaggs, B. J. Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells. Arthritis Rheumatol. 66, 674–685 (2014).
[DOI: 10.1002/art.38259]
- Vlachou, K. et al. Elimination of granulocytic myeloid-derived suppressor cells in lupus-prone mice linked to reactive oxygen species-dependent extracellular trap formation. Arthritis Rheumatol. 68, 449–461 (2016).
[DOI: 10.1002/art.39441]
- Shi, G. et al. mTOR inhibitor INK128 attenuates systemic lupus erythematosus by regulating inflammation-induced CD11b(+)Gr1(+) cells. Biochim. Biophys. Acta Mol. Basis Dis. 1865, 1–13 (2019).
[DOI: 10.1016/j.bbadis.2018.10.007]
- Zhang, D. et al. Myeloid-derived suppressor cells induce podocyte injury through increasing reactive oxygen species in lupus nephritis. Front. Immunol. 9, 1443 (2018).
[DOI: 10.3389/fimmu.2018.01443]
- Li, D. et al. Baicalein ameliorates pristane-induced lupus nephritis via activating Nrf2/HO-1 in myeloid-derived suppressor cells. Arthritis Res. Ther. 21, 105 (2019).
[DOI: 10.1186/s13075-019-1876-0]
- Rahman, S. et al. Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus. Ann. Rheum. Dis. 78, 957–966 (2019).
[DOI: 10.1136/annrheumdis-2018-214620]
- 91542113/National Natural Science Foundation of China (National Science Foundation of China)
- BK20180825/Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation)
Animals
Autoimmune Diseases
Cellular Microenvironment
Humans
Infections
Lupus Erythematosus, Systemic
Mice
Myeloid-Derived Suppressor Cells
Neoplasms
T-Lymphocytes
