Estimation on conditional restricted mean survival time with counting process.

Junshan Qiu, Ennan Gu, Dali Zhou, John Lawrence, Steven Bai, Hsien Ming J Hung
Author Information
  1. Junshan Qiu: Division of Biometrics I, OB/OTS/CDER, US FDA , Silver Spring , Maryland , USA.
  2. Ennan Gu: Department of Statistics, University of South Carolina , Columbia , SC , USA.
  3. Dali Zhou: Department of Mathematical Sciences, Indiana University - Purdue University Indianapolis (IUPUI) , Indianapolis , IN , USA.
  4. John Lawrence: Division of Biometrics I, OB/OTS/CDER, US FDA , Silver Spring , Maryland , USA.
  5. Steven Bai: Division of Biometrics I, OB/OTS/CDER, US FDA , Silver Spring , Maryland , USA.
  6. Hsien Ming J Hung: Division of Biometrics I, OB/OTS/CDER, US FDA , Silver Spring , Maryland , USA.

Abstract

In traditional survival analyses, hazard ratio (HR) is commonly used to evaluate treatment effects. However, HR may not be easy to interpret. Restricted mean survival time is a viable alternative to HR, particularly when the proportional hazards assumption is not satisfied. We developed a conditional restricted mean survival time (CRMST) estimator for a time interval of interest using counting process. The variance of CRMST was estimated using a perturbation re-sampling method for asymptotic normality. The utility of our CRMST seems promising based on comprehensive simulation studies and a real data case study.

Keywords

MeSH Term

Cardiovascular Diseases
Double-Blind Method
Follow-Up Studies
Humans
Platelet Aggregation Inhibitors
Proportional Hazards Models
Randomized Controlled Trials as Topic
Stochastic Processes
Survival Rate

Chemicals

Platelet Aggregation Inhibitors

Word Cloud

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