The PHD finger of Spp1 mediates histone modification cross-talk.
Catherine A Musselman, Tatiana G Kutateladze
Author Information
Catherine A Musselman: Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, U.S.A. tatiana.kutateladze@cuanschutz.edu catherine.musselman@cuanschutz.edu.
Tatiana G Kutateladze: Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, U.S.A. tatiana.kutateladze@cuanschutz.edu catherine.musselman@cuanschutz.edu. ORCID
Binding of the Spp1 PHD finger to histone H3K4me3 is sensitive to adjacent post-translational modifications in the histone tail. This commentary discusses the findings of He and colleagues [, 1957-1973] which show that the PHD finger binds to H3K4me3 in a selective manner which is conserved in the and mammalian orthologues of Spp1.
