Hypercalcaemia secondary to disseminated Mycobacterium abscessus and Mycobacterium fortuitum.

Navin Kuthiah, Er Chaozer
Author Information
  1. Navin Kuthiah: WHC Office, Level 5, Tower E, Yishun Community Hospital, 2 Yishun Central 2, 768024, Singapore, navin_kuthiah@whc.sg.
  2. Er Chaozer: Internal Medicine, Woodlands Health Campus, Yishun, Singapore.

Abstract

The incidence and prevalence of nontuberculous mycobacteria (NTM) infection is on the rise with many cases still going unreported. Given the vague and nonspecific clinical features of NTM infections, it is often missed or mistaken for Mycobacterium tuberculosis. The presumption that NTM infections are benign and do not contribute to morbidity no longer holds true. NTM infections need to be considered in patients with disseminated multisystem disease and in those not responding to standard M. tuberculosis treatment. As NTM infection is associated with granuloma formation, it can result in hypercalcaemia. Interestingly, there is evidence that there may be other mechanisms in play contributing to hypercalcaemia besides the increased calcitriol levels.

Keywords

MeSH Term

Aged
Anti-Bacterial Agents
Antibodies
Cefoxitin
Ciprofloxacin
Clarithromycin
Doxycycline
Drug Therapy, Combination
Female
Granuloma
Humans
Hypercalcemia
Interferons
Liver
Macrophage Colony-Stimulating Factor
Mycobacterium Infections, Nontuberculous
Mycobacterium abscessus
Mycobacterium fortuitum
Singapore

Chemicals

Anti-Bacterial Agents
Antibodies
Ciprofloxacin
Cefoxitin
Macrophage Colony-Stimulating Factor
Interferons
Clarithromycin
Doxycycline

Word Cloud

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