Hepatitis C Treatment Cascade in a Federally Qualified Health Center.

David M Hachey, John T Holmes, Nicki L Aubuchon-Endsley
Author Information
  1. David M Hachey: Department of Family Medicine, Idaho State University, 921 S. 8th Ave. Stop, Pocatello, ID, 83209, USA. hachdavi@isu.edu. ORCID
  2. John T Holmes: Department of Family Medicine, Idaho State University, 921 S. 8th Ave. Stop, Pocatello, ID, 83209, USA.
  3. Nicki L Aubuchon-Endsley: Department of Psychology, Idaho State University, Pocatello, ID, USA.

Abstract

Hepatitis C (HCV) care cascades have been described in diverse clinical settings, patient populations and countries, highlighting the steps in HCV care where improvements can be made and resources allocated. However, more research is needed to examine barriers to HCV treatment in rural, underserved populations and in Federally Qualified Health Centers (FQHCs). As part of a quality improvement (QI) project, this study aimed to describe and evaluate the HCV treatment cascade in an FQHC serving a large rural patient population in the Western United States. Standardized chart abstraction was utilized to aggregate data regarding patient demographics, the percentage of patients achieving each step in the treatment cascade, and relevant patient (i.e., viral load) and service variables (i.e., whether and when patients received treatment or medication). 389 patients were identified as having HCV and 86% were aware of their diagnosis. Fifty-five percent had their infection confirmed via viral load, 21% were staged for liver disease, 24% received a prescription for treatment, and 19% achieved cure. Compared to national data, the current regional sample had greater rates of diagnosis awareness and access to care, as well as sustained virologic response (SVR), but lower rates of viral load confirmation. Current findings suggest that rural patients living with HCV who receive care at FQHCs struggle to navigate the treatment cascade and achieve a cure, particularly with regard to infection confirmation, liver staging, and prescription. However, compared to national estimates, patients had greater rates of diagnosis awareness/treatment access and SVR.

Keywords

References

  1. Clin Infect Dis. 2013 Jan;56(1):40-50 [PMID: 22990852]
  2. MMWR Morb Mortal Wkly Rep. 2016 May 13;65(18):461-6 [PMID: 27172175]
  3. Liver Int. 2013 Aug;33(7):999-1007 [PMID: 23509897]
  4. J Viral Hepat. 2013 Aug;20(8):550-5 [PMID: 23808993]
  5. Dig Dis Sci. 2007 Oct;52(10):2550-6 [PMID: 17406823]
  6. Clin Gastroenterol Hepatol. 2012 Nov;10(11):1270-1277.e3 [PMID: 22841970]
  7. PLoS One. 2015 Nov 12;10(11):e0142770 [PMID: 26562516]
  8. Ann Intern Med. 2017 Sep 5;167(5):311-318 [PMID: 28785771]
  9. J Hepatol. 2012 Aug;57(2):252-9 [PMID: 22521358]
  10. J Community Med Health Educ. 2016 Oct;6(5): [PMID: 28083156]
  11. MMWR Morb Mortal Wkly Rep. 2016 Oct 21;65(41):1132-1135 [PMID: 27764081]
  12. PLoS One. 2014 Jul 02;9(7):e101554 [PMID: 24988388]
  13. Ann Intern Med. 2010 Aug 17;153(4):231-9 [PMID: 20713791]
  14. Clin Infect Dis. 2011 Mar 15;52(6):793-800 [PMID: 21367734]
  15. Clin Infect Dis. 2016 May 15;62(10):1290-1296 [PMID: 26908812]
  16. N Engl J Med. 2011 Jun 9;364(23):2199-207 [PMID: 21631316]
  17. Fam Med. 2016 Sep;48(8):631-4 [PMID: 27655196]
  18. PLoS One. 2014 Jul 18;9(7):e102883 [PMID: 25036553]
  19. Ann Intern Med. 2012 Dec 4;157(11):817-22 [PMID: 22910836]
  20. EBioMedicine. 2016 Oct;12:189-195 [PMID: 27596150]

MeSH Term

Antiviral Agents
Health Knowledge, Attitudes, Practice
Health Services Accessibility
Hepatitis C
Humans
Medically Underserved Area
Rural Health Services
Safety-net Providers
Sustained Virologic Response
United States
Viral Load
Vulnerable Populations

Chemicals

Antiviral Agents

Word Cloud

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