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Nutrients
Sep 15, 2019;11 (9):

Interdisciplinary Weight Loss and Lifestyle Intervention for Obstructive Sleep Apnoea in Adults: Rationale, Design and Methodology of the INTERAPNEA Study.

Almudena Carneiro-Barrera, Francisco J Amaro-Gahete, Amparo Díaz-Román, Alejandro Guillén-Riquelme, Lucas Jurado-Fasoli, Germán Sáez-Roca, Carlos Martín-Carrasco, Jonatan R Ruiz, Gualberto Buela-Casal
Author Information
  1. Almudena Carneiro-Barrera: Sleep and Health Promotion Laboratory, Mind, Brain and Behaviour Research Centre (CIMCYC), University of Granada, 18011 Granada, Spain. acarneiro@ugr.es.
  2. Francisco J Amaro-Gahete: EFFECTS-262 Research group, Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain. amarof@ugr.es. ORCID
  3. Amparo Díaz-Román: Sleep and Health Promotion Laboratory, Mind, Brain and Behaviour Research Centre (CIMCYC), University of Granada, 18011 Granada, Spain. adiazroman@ugr.es. ORCID
  4. Alejandro Guillén-Riquelme: Sleep and Health Promotion Laboratory, Mind, Brain and Behaviour Research Centre (CIMCYC), University of Granada, 18011 Granada, Spain. agr@ugr.es.
  5. Lucas Jurado-Fasoli: EFFECTS-262 Research group, Department of Medical Physiology, School of Medicine, University of Granada, 18071 Granada, Spain. juradofasoli@ugr.es. ORCID
  6. Germán Sáez-Roca: Unidad de Trastornos Respiratorios del Sueño, Servicio de Neumología, "Virgen de las Nieves" University Hospital, 18014 Granada, Spain. gsaezroca@gmail.com.
  7. Carlos Martín-Carrasco: Unidad de Trastornos Respiratorios del Sueño, Servicio de Neumología, "Virgen de las Nieves" University Hospital, 18014 Granada, Spain. cmartincarrasco@gmail.com.
  8. Jonatan R Ruiz: PROmoting FITness and Health through physical activity research group (PROFITH), Sport and Health University Research Institute (iMUDS), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain. ruizj@ugr.es.
  9. Gualberto Buela-Casal: Sleep and Health Promotion Laboratory, Mind, Brain and Behaviour Research Centre (CIMCYC), University of Granada, 18011 Granada, Spain. gbuela@ugr.es.
PMID: 31540168 DOI: 10.3390/nu11092227

Abstract

Obesity is a major risk factor for obstructive sleep apnoea (OSA), the most common sleep-disordered breathing related to neurocognitive and metabolic syndromes, type II diabetes, and cardiovascular diseases. Although strongly recommended for this condition, there are no studies on the effectiveness of an interdisciplinary weight loss and lifestyle intervention including nutrition, exercise, sleep hygiene, and smoking and alcohol cessation. INTERAPNEA is a randomised controlled trial with a two-arm parallel design aimed at determining the effects of an interdisciplinary tailored weight loss and lifestyle intervention on OSA outcomes. The study will include 84 males aged 18-65 with a body mass index of ≥25 kg/m and severe to moderate OSA randomly assigned to usual care (i.e., continuous positive airway pressure), or interdisciplinary weight loss and lifestyle intervention combined with usual care. Outcomes will be measured at baseline, intervention end-point, and six-month post-intervention, including apnoea-hypopnoea index (primary outcome), other neurophysical and cardiorespiratory polysomnographic outcomes, sleep quality, daily functioning and mood, body weight and composition, physical fitness, blood biomarkers, health-related quality of life, and cost-effectiveness. INTERAPNEA may serve to establish a cost-effective treatment not only for the improvement of OSA and its vast and severe comorbidities, but also for a potential remission of this condition.

Keywords

alcohol apnoea-hypopnoea index exercise interdisciplinary lifestyle intervention nutrition obesity obstructive sleep apnoea sleep hygiene smoking weight loss

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Grants

  1. FPU16/01093 and FPU14/04172/Ministerio de Educación, Cultura y Deporte
  2. SOMM17/6107/UGR/Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades
  3. Excellence actions: Unit of Excellence on Exercise and Health (UCEES)/University of Granada Plan Propio de Investigación 2016
  4. Sleep Research Cathedra University of Granada-LoMonaco S.L./Sleep Research Cathedra University of Granada-LoMonaco S.L.

MeSH Term

Adult
Biomarkers
Body Weight
Exercise Therapy
Humans
Life Style
Male
Middle Aged
Sleep Apnea, Obstructive
Weight Reduction Programs
Young Adult

Chemicals

Biomarkers
Journal Article Randomized Controlled Trial

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