Venetoclax: A Review in Relapsed/Refractory Chronic Lymphocytic Leukemia.

Lesley J Scott
Author Information
  1. Lesley J Scott: Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand. demail@springer.com.

Abstract

Venetoclax (Venclyxto; Venclexta) is a first-in-class, oral, selective B cell lymphoma-2 (BCL-2) inhibitor. The drug is approved in numerous countries, including those of the EU and in the USA, for the treatment of adults with relapsed or refractory (RR) chronic lymphocytic leukemia (CLL); the specific indication(s) for venetoclax may vary between individual countries. Venetoclax monotherapy or combination therapy with rituximab was an effective treatment, provided durable responses, and had a manageable safety profile in pivotal clinical trials in adults with RR CLL, including in patients with adverse prognostic factors. In combination with 6 cycles of rituximab, venetoclax (fixed 24 months' treatment) was more effective than bendamustine plus rituximab (6 cycles) in prolonging progression-free survival (PFS) and inducing undetectable minimal residual disease (uMRD) in peripheral blood (PB) and bone marrow (BM), with these benefits sustained during 36 months' follow-up. Hence, with its novel mechanism of action and convenient oral once-daily regimen, venetoclax monotherapy or fixed 24-month combination therapy with rituximab represents an important option for treating RR CLL, including in patients with del(17p) or TP53 mutation and those failing a B cell receptor (BCR) inhibitor and/or chemotherapy.

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MeSH Term

Adult
Antineoplastic Agents
Bridged Bicyclo Compounds, Heterocyclic
Drug Resistance, Neoplasm
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Proto-Oncogene Proteins c-bcl-2
Recurrence
Remission Induction
Sulfonamides
Survival Analysis

Chemicals

Antineoplastic Agents
Bridged Bicyclo Compounds, Heterocyclic
Proto-Oncogene Proteins c-bcl-2
Sulfonamides
venetoclax

Word Cloud

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