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International journal of molecular sciences
Sep 30, 2019;20 (19):

ILC2 Activation by Protozoan Commensal Microbes.

Kyle Burrows, Louis Ngai, Flora Wong, David Won, Arthur Mortha
Author Information
  1. Kyle Burrows: University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. kyle.burrows@utoronto.ca. ORCID
  2. Louis Ngai: University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. louis.ngai@mail.utoronto.ca. ORCID
  3. Flora Wong: University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. fl.wong@mail.utoronto.ca.
  4. David Won: University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. taehyoan.won@mail.utoronto.ca.
  5. Arthur Mortha: University of Toronto, Department of Immunology, Toronto, ON M5S 1A8, Canada. arthur.mortha@utoronto.ca.
PMID: 31574995 DOI: 10.3390/ijms20194865

Abstract

Group 2 innate lymphoid cells (ILC2s) are a member of the ILC family and are involved in protective and pathogenic type 2 responses. Recent research has highlighted their involvement in modulating tissue and immune homeostasis during health and disease and has uncovered critical signaling circuits. While interactions of ILC2s with the bacterial microbiome are rather sparse, other microbial members of our microbiome, including helminths and protozoans, reveal new and exciting mechanisms of tissue regulation by ILC2s. Here we summarize the current field on ILC2 activation by the tissue and immune environment and highlight particularly new intriguing pathways of ILC2 regulation by protozoan commensals in the intestinal tract.

Keywords

ILC2 Trichomonas Tritrichomonas musculis commensals intestinal immunity mucosal immunity protozoa succinate taste receptors type 2 immunity

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Grants

  1. 388337/CIHR
  2. RGPIN-2019-04521/Natural Sciences and Engineering Research Council of Canada

MeSH Term

Animals
Biomarkers
Cytokines
Humans
Immunity, Innate
Immunomodulation
Lymphocyte Activation
Lymphocyte Subsets
Microbiota
Parasites
Signal Transduction

Chemicals

Biomarkers
Cytokines
Journal Article Review
Article has an altmetric score of 8

Word Cloud

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