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Nov 18, 2019;40 (6): 488-505.

Antimicrobial peptides: new hope in the war against multidrug resistance.

James Mwangi, Xue Hao, Ren Lai, Zhi-Ye Zhang
Author Information
  1. James Mwangi: Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
  2. Xue Hao: Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
  3. Ren Lai: Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.
  4. Zhi-Ye Zhang: Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China, E-mail:zhangzhiye@mail.kiz.ac.cn.
PMID: 31592585 DOI: 10.24272/j.issn.2095-8137.2019.062

Abstract

The discovery of antibiotics marked a golden age in the revolution of human medicine. However, decades later, bacterial infections remain a global healthcare threat, and a return to the pre-antibiotic era seems inevitable if stringent measures are not adopted to curb the rapid emergence and spread of multidrug resistance and the indiscriminate use of antibiotics. In hospital settings, multidrug resistant (MDR) pathogens, including carbapenem-resistant , vancomycin-resistant enterococci (VRE), methicillin-resistant (MRSA), and extended-spectrum ��-lactamases (ESBL) bearing , , and are amongst the most problematic due to the paucity of treatment options, increased hospital stay, and exorbitant medical costs. Antimicrobial peptides (AMPs) provide an excellent potential strategy for combating these threats. Compared to empirical antibiotics, they show low tendency to select for resistance, rapid killing action, broad-spectrum activity, and extraordinary clinical efficacy against several MDR strains. Therefore, this review highlights multidrug resistance among nosocomial bacterial pathogens and its implications and reiterates the importance of AMPs as next-generation antibiotics for combating MDR superbugs.

Keywords

Antibiotic alternatives Antimicrobial peptide Multidrug resistance Nosocomial infections

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Grants

  1. XDB31000000/Chinese Academy of Sciences
  2. EP-W-17-011/EPA
  3. XDB31000000,SAJC201606,KFZD-SW-219- 2,KFJ-BRP-008,KGFZD-135-17-011/Chinese Academy of Sciences
  4. 2015HA023/Yunnan Province Grant
  5. 21761142002 and 31801975/the National Natural Science Foundation of China

MeSH Term

Animals
Anti-Bacterial Agents
Antimicrobial Cationic Peptides
Bacteria
Cross Infection
Drug Resistance, Multiple, Bacterial
Humans

Chemicals

Anti-Bacterial Agents
Antimicrobial Cationic Peptides
Journal Article Review
Article has an altmetric score of 2

Word Cloud

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