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Molecules (Basel, Switzerland)
Oct 28, 2019;24 (21):

Recent Advances in the Discovery of Novel Antiprotozoal Agents.

Seong-Min Lee, Min-Sun Kim, Faisal Hayat, Dongyun Shin
Author Information
  1. Seong-Min Lee: College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea. minlee0405@gmail.com.
  2. Min-Sun Kim: College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea. ms9404@hanmail.net.
  3. Faisal Hayat: College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea. faisalchem80@yahoo.com.
  4. Dongyun Shin: College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Korea. dyshin@gachon.ac.kr.
PMID: 31661934 DOI: 10.3390/molecules24213886

Abstract

Parasitic diseases have serious health, social, and economic impacts, especially in the tropical regions of the world. Diseases caused by protozoan parasites are responsible for considerable mortality and morbidity, affecting more than 500 million people worldwide. Globally, the burden of protozoan diseases is increasing and is been exacerbated because of a lack of effective medication due to the drug resistance and toxicity of current antiprotozoal agents. These limitations have prompted many researchers to search for new drugs against protozoan parasites. In this review, we have compiled the latest information (2012-2017) on the structures and pharmacological activities of newly developed organic compounds against five major protozoan diseases, giardiasis, leishmaniasis, malaria, trichomoniasis, and trypanosomiasis, with the aim of showing recent advances in the discovery of new antiprotozoal drugs.

Keywords

giardiasis leishmaniasis malaria parasitic protozoan diseases trichomoniasis trypanosomiasis

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MeSH Term

Animals
Antiprotozoal Agents
Drug Resistance
Parasites
Parasitic Diseases

Chemicals

Antiprotozoal Agents
Journal Article Review
Article has an altmetric score of 4

Word Cloud

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