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11 06, 2019;4 (6):

Insights into the Host Range, Genetic Diversity, and Geographical Distribution of Jingmenviruses.

Sarah Temmam, Thomas Bigot, Delphine Chrétien, Mathilde Gondard, Philippe Pérot, Virginie Pommelet, Evelyne Dufour, Stéphane Petres, Elodie Devillers, Thavry Hoem, Valérie Pinarello, Vibol Hul, Khamsing Vongphayloth, Jeffrey C Hertz, Irène Loiseau, Marine Dumarest, Veasna Duong, Muriel Vayssier-Taussat, Marc Grandadam, Emmanuel Albina, Philippe Dussart, Sara Moutailler, Julien Cappelle, Paul T Brey, Marc Eloit
Author Information
  1. Sarah Temmam: Institut Pasteur, Biology of Infection Unit, Inserm U1117, Pathogen Discovery Laboratory, Institut Pasteur, Paris, France.
  2. Thomas Bigot: Institut Pasteur, Biology of Infection Unit, Inserm U1117, Pathogen Discovery Laboratory, Institut Pasteur, Paris, France. ORCID
  3. Delphine Chrétien: Institut Pasteur, Biology of Infection Unit, Inserm U1117, Pathogen Discovery Laboratory, Institut Pasteur, Paris, France.
  4. Mathilde Gondard: UMR ASTRE, CIRAD, INRA, Université de Montpellier, Montpellier, France.
  5. Philippe Pérot: Institut Pasteur, Biology of Infection Unit, Inserm U1117, Pathogen Discovery Laboratory, Institut Pasteur, Paris, France.
  6. Virginie Pommelet: Institut Pasteur du Laos, Vientiane, Lao People's Democratic Republic.
  7. Evelyne Dufour: Institut Pasteur, Production and Purification of Recombinant Proteins Technological Platform-C2RT, Institut Pasteur, Paris, France.
  8. Stéphane Petres: Institut Pasteur, Production and Purification of Recombinant Proteins Technological Platform-C2RT, Institut Pasteur, Paris, France.
  9. Elodie Devillers: UMR BIPAR, Animal Health Laboratory, ANSES, INRA, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, Maisons-Alfort, France.
  10. Thavry Hoem: Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
  11. Valérie Pinarello: UMR ASTRE, CIRAD, INRA, Université de Montpellier, Montpellier, France.
  12. Vibol Hul: Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
  13. Khamsing Vongphayloth: Institut Pasteur du Laos, Vientiane, Lao People's Democratic Republic.
  14. Jeffrey C Hertz: U.S. NAMRU 2, NMRCA, Singapore.
  15. Irène Loiseau: Institut Pasteur, Biology of Infection Unit, Inserm U1117, Pathogen Discovery Laboratory, Institut Pasteur, Paris, France.
  16. Marine Dumarest: Institut Pasteur, Biology of Infection Unit, Inserm U1117, Pathogen Discovery Laboratory, Institut Pasteur, Paris, France.
  17. Veasna Duong: Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia. ORCID
  18. Muriel Vayssier-Taussat: UMR BIPAR, Animal Health Laboratory, ANSES, INRA, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, Maisons-Alfort, France.
  19. Marc Grandadam: Institut Pasteur du Laos, Vientiane, Lao People's Democratic Republic.
  20. Emmanuel Albina: UMR ASTRE, CIRAD, INRA, Université de Montpellier, Montpellier, France.
  21. Philippe Dussart: Virology Unit, Institut Pasteur du Cambodge, Institut Pasteur International Network, Phnom Penh, Cambodia.
  22. Sara Moutailler: UMR BIPAR, Animal Health Laboratory, ANSES, INRA, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, Maisons-Alfort, France.
  23. Julien Cappelle: UMR ASTRE, CIRAD, INRA, Université de Montpellier, Montpellier, France.
  24. Paul T Brey: Institut Pasteur du Laos, Vientiane, Lao People's Democratic Republic.
  25. Marc Eloit: Institut Pasteur, Biology of Infection Unit, Inserm U1117, Pathogen Discovery Laboratory, Institut Pasteur, Paris, France marc.eloit@pasteur.fr.
PMID: 31694898 DOI: 10.1128/mSphere.00645-19

Abstract

Jingmenvirus is a recently identified group of segmented RNA viruses phylogenetically linked with unsegmented viruses. Primarily identified in various tick genera originating in China, Jingmenvirus geographical distribution has rapidly expanded to cover Africa, South America, Caribbean, and Europe. The identification of Jingmen-related viruses in various mammals, including febrile humans, opens the possibility that Jingmenviruses may be novel tick-borne arboviruses. In this study, we aimed at increasing knowledge of the host range, genetic diversity, and geographical distribution of Jingmenviruses by reporting for the first time the identification of Jingmenviruses associated with ticks originating in the French Antilles (Guadeloupe and Martinique islands), with ticks in Lao PDR, and with ticks in metropolitan France, and from urine of bats in Cambodia. Analyses of the relationships between the different Jingmenvirus genomes resulted in the identification of three main phylogenic subclades, each of them containing both tick-borne and mammal-borne strains, reinforcing the idea that Jingmenviruses may be considered as tick-borne arboviruses. Finally, we estimated the prevalence of Jingmenvirus-like infection using luciferase immunoprecipitation assay screening (LIPS) of asymptomatic humans and cattle highly exposed to tick bites. Among 70 French human, 153 Laotian human, and 200 Caribbean cattle sera tested, only one French human serum was found (slightly) positive, suggesting that the prevalence of Jingmenvirus human and cattle infections in these areas is probably low. Several arboviruses emerging as new pathogens for humans and domestic animals have recently raised public health concern and increased interest in the study of their host range and in detection of spillover events. Recently, a new group of segmented -related viruses, the Jingmenviruses, has been identified worldwide in many invertebrate and vertebrate hosts, pointing out the issue of whether they belong to the arbovirus group. The study presented here combined whole-genome sequencing of three tick-borne Jingmenviruses and one bat-borne Jingmenvirus with comprehensive phylogenetic analyses and high-throughput serological screening of human and cattle populations exposed to these viruses to contribute to the knowledge of Jingmenvirus host range, geographical distribution, and mammalian exposure.

Keywords

Jingmenvirus LIPS emergence evolution

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MeSH Term

Animals
Cattle
Chiroptera
Filoviridae Infections
Flaviviridae
Genetic Variation
Global Health
Host Specificity
Humans
Phylogeography
Ticks
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 8

Word Cloud

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