Applying the 3Rs: A Case Study on Evidence and Perceptions Relating to Rat Cage Height in the UK.

Hibba Mazhary, Penny Hawkins
Author Information
  1. Hibba Mazhary: School of Geography and the Environment, University of Oxford, Oxford, OX1 3QY, UK.
  2. Penny Hawkins: Research Animals Department, RSPCA , Wilberforce Way, Southwater, West Sussex RH13 9RS, UK.

Abstract

This article investigates the barriers to implementing higher caging in animal research establishments in the UK. The use of animals in research and testing in the UK is regulated by the Animals (Scientific Procedures) Act 1986, which sets out how animal experiments must be licensed and regulated. Within this, the Code of Practice currently allows laboratory rats to be housed in cages that are 20 cm high, even though adults can rear up to 30 cm. Most adult rats therefore cannot stand upright in 'standard' cages. We found that the main factors hindering the implementation of higher caging were classified into five different groups; health and safety, financial, animal welfare, scientific, and 'human'. Suggestions to overcome these barriers are provided, as well as alternative animal welfare changes that can be put into place. We conclude that much of the desired evidence for moving to higher cages is already available, and therefore the focus should be on education and improving access to the existing evidence, in order to encourage facilities to work around existing financial and health and safety concerns.

Keywords

References

  1. Animals (Basel). 2019 Jul 13;9(7):null [PMID: 31337042]
  2. Sci Technol Human Values. 2018 Jul;43(4):694-722 [PMID: 30008494]
  3. J Pharmacol Toxicol Methods. 2019 Mar - Apr;96:87-94 [PMID: 30779962]
  4. J Comp Physiol Psychol. 1977 Jun;91(3):649-61 [PMID: 559696]
  5. ILAR J. 2005;46(2):162-70 [PMID: 15775025]
  6. Lab Anim. 1998 Jan;32(1):23-35 [PMID: 9481691]
  7. J Musculoskelet Neuronal Interact. 2001 Mar;1(3):241-7 [PMID: 15758498]
  8. J Exp Anim Sci. 1993 Oct;36(1):19-26 [PMID: 8312384]
  9. Animals (Basel). 2017 Aug 09;7(8):null [PMID: 28792485]
  10. PLoS One. 2016 Jan 28;11(1):e0147595 [PMID: 26820978]
  11. Lab Anim. 1996 Jul;30(3):234-44 [PMID: 8843048]
  12. PLoS One. 2012;7(10):e47640 [PMID: 23091636]
  13. Animals (Basel). 2016 Mar 14;6(3):null [PMID: 27102171]
  14. Contemp Top Lab Anim Sci. 2003 Mar;42(2):46-8 [PMID: 19757626]
  15. Exp Anim. 2016 Nov 1;65(4):383-392 [PMID: 27263962]
  16. Lab Anim. 2015 Jan;49(1):10-9 [PMID: 25117586]
  17. Animals (Basel). 2018 Dec 05;8(12):null [PMID: 30563104]
  18. R Soc Open Sci. 2016 Jun 29;3(6):160136 [PMID: 27429772]

Grants

  1. N/A/Royal Society for the Prevention of Cruelty to Animals

Word Cloud

Created with Highcharts 10.0.0animalwelfarehigherUKcagesevidencebarrierscagingresearchanimalsregulatedlaboratoryratscmcanthereforehealthsafetyfinancialexistingratarticleinvestigatesimplementingestablishmentsusetestingAnimalsScientificProceduresAct1986setsexperimentsmustlicensedWithinCodePracticecurrentlyallowshoused20higheventhoughadultsrear30adultstandupright'standard'foundmainfactorshinderingimplementationclassifiedfivedifferentgroupsscientific'human'SuggestionsovercomeprovidedwellalternativechangesputplaceconcludemuchdesiredmovingalreadyavailablefocuseducationimprovingaccessorderencouragefacilitiesworkaroundconcernsApplying3Rs:CaseStudyEvidencePerceptionsRelatingRatCageHeight3Rshusbandryanthropomorphismbehaviourchangerefinement

Similar Articles

Cited By