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Mediators of inflammation
2019;2019 8971036.

Experimental Abdominal Sepsis: Sticking to an Awkward but Still Useful Translational Model.

Federica Murando, Andrea Peloso, Lorenzo Cobianchi
Author Information
  1. Federica Murando: General Surgery Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
  2. Andrea Peloso: Hepatology and Transplantation Laboratory, Department of Surgery, Faculty of Medicine, University of Geneva, Geneva, Switzerland. ORCID
  3. Lorenzo Cobianchi: General Surgery Department, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
PMID: 31885502 DOI: 10.1155/2019/8971036

Abstract

Animal models are widely used to replicate human intra-abdominal infections. Different methodologies have been described and proposed in the scientific literature, including injection and surgical models. The aim of this review is to recapitulate the advantages and disadvantages of each method to help choose the most appropriate model for individual experimental purposes.

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MeSH Term

Animals
Disease Models, Animal
Humans
Lipopolysaccharides
Peritonitis
Sepsis

Chemicals

Lipopolysaccharides
Journal Article Review

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