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Chemical communications (Cambridge, England)
Jan 23, 2020;56 (7): 1085-1088.

Elastase-triggered HS delivery from polymer hydrogels.

Mingjun Zhou, Yun Qian, Yumeng Zhu, John Matson
Author Information
  1. Mingjun Zhou: Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, Virginia 24061, USA. jbmatson@vt.edu.
PMID: 31894779 DOI: 10.1039/c9cc08752d

Abstract

We report an elastase-responsive, H2S-releasing hydrogel prepared by covalently crosslinking a mixture of carboxymethylcellulose and poly(ethylene glycol) with an elastase-degradable peptide functionalized with an H2S-releasing S-aroylthiooxime (SATO) unit. Addition of elastase triggered a gel-to-sol transition, which exposed SATOs, leading to more and longer H2S release compared to untriggered gels.

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Grants

  1. R01 GM123508/NIGMS NIH HHS

MeSH Term

Animals
Carboxymethylcellulose Sodium
Cell Line
Doxorubicin
Humans
Hydrogels
Hydrogen Sulfide
Leukocyte Elastase
Oxidative Stress
Oximes
Polyethylene Glycols
Protective Agents
Rats

Chemicals

Hydrogels
Oximes
Protective Agents
Polyethylene Glycols
Doxorubicin
ELANE protein, human
Leukocyte Elastase
Carboxymethylcellulose Sodium
Hydrogen Sulfide
Journal Article
Article has an altmetric score of 3

Word Cloud

Created with Highcharts 10.0.0H2S-releasingreportelastase-responsivehydrogelpreparedcovalentlycrosslinkingmixturecarboxymethylcellulosepolyethyleneglycolelastase-degradablepeptidefunctionalizedS-aroylthiooximeSATOunitAdditionelastasetriggeredgel-to-soltransitionexposedSATOsleadinglongerH2SreleasecompareduntriggeredgelsElastase-triggeredHSdeliverypolymerhydrogels

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