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Jan, 2020;7 (1): 1901872.

Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections.

Yu-Xuan Ma, Chen-Yu Wang, Yuan-Yuan Li, Jing Li, Qian-Qian Wan, Ji-Hua Chen, Franklin R Tay, Li-Na Niu
Author Information
  1. Yu-Xuan Ma: State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China.
  2. Chen-Yu Wang: State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China.
  3. Yuan-Yuan Li: State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China.
  4. Jing Li: State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China.
  5. Qian-Qian Wan: State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China.
  6. Ji-Hua Chen: State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China.
  7. Franklin R Tay: State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China. ORCID
  8. Li-Na Niu: State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Key Laboratory of Stomatology Department of Prosthodontics School of Stomatology The Fourth Military Medical University 145 Changle West Road Xi'an Shaanxi 710032 P. R. China.
PMID: 31921562 DOI: 10.1002/advs.201901872

Abstract

ESKAPE pathogens (, , , , , and species) are among the most common opportunistic pathogens in nosocomial infections. ESKAPE pathogens distinguish themselves from normal ones by developing a high level of antibiotic resistance that involves multiple mechanisms. Contemporary therapeutic strategies which are potential options in combating ESKAPE bacteria need further investigation. Herein, a broad overview of the antimicrobial research on ESKAPE pathogens over the past five years is provided with prospective clinical applications.

Keywords

antimicrobial peptides antiresistance antivirulence bacteriophages nanodelivery strategies

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