Genomics Education in the Era of Personal Genomics: Academic, Professional, and Public Considerations.

Kiara V Whitley, Josie A Tueller, K Scott Weber
Author Information
  1. Kiara V Whitley: Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, 701 East University Parkway, Brigham Young University, Provo, UT 84602, USA.
  2. Josie A Tueller: Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, 701 East University Parkway, Brigham Young University, Provo, UT 84602, USA.
  3. K Scott Weber: Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, 701 East University Parkway, Brigham Young University, Provo, UT 84602, USA.

Abstract

Since the completion of the Human Genome Project in 2003, genomic sequencing has become a prominent tool used by diverse disciplines in modern science. In the past 20 years, the cost of genomic sequencing has decreased exponentially, making it affordable and accessible. Bioinformatic and biological studies have produced significant scientific breakthroughs using the wealth of genomic information now available. Alongside the scientific benefit of genomics, companies offer direct-to-consumer genetic testing which provide health, trait, and ancestry information to the public. A key area that must be addressed is education about what conclusions can be made from this genomic information and integrating genomic education with foundational genetic principles already taught in academic settings. The promise of personal genomics providing disease treatment is exciting, but many challenges remain to validate genomic predictions and diagnostic correlations. Ethical and societal concerns must also be addressed regarding how personal genomic information is used. This genomics revolution provides a powerful opportunity to educate students, clinicians, and the public on scientific and ethical issues in a personal way to increase learning. In this review, we discuss the influence of personal genomics in society and focus on the importance and benefits of genomics education in the classroom, clinics, and the public and explore the potential consequences of personal genomic education.

Keywords

References

  1. Forensic Sci Int. 2019 Aug;301:107-117 [PMID: 31153988]
  2. Int Nurs Rev. 2019 Dec;66(4):459-466 [PMID: 31313831]
  3. PeerJ. 2013 Feb 12;1:e8 [PMID: 23638402]
  4. Ann Intern Med. 2016 Apr 19;164(8):513-22 [PMID: 26928821]
  5. Biochem Mol Biol Educ. 2019 Nov;47(6):632-637 [PMID: 31403746]
  6. Clin J Oncol Nurs. 2017 Dec 1;21(6):747-753 [PMID: 29149120]
  7. J Nurs Scholarsh. 2018 May;50(3):249-256 [PMID: 29608246]
  8. Lancet. 2018 Jun 16;391(10138):2463-2474 [PMID: 29916387]
  9. Per Med. 2009 Nov 1;6(6):681 [PMID: 20161675]
  10. Genet Test Mol Biomarkers. 2014 Mar;18(3):131-40 [PMID: 24495163]
  11. Acad Med. 2011 Aug;86(8):925-7 [PMID: 21795901]
  12. PLoS Biol. 2018 Oct 2;16(10):e2006906 [PMID: 30278047]
  13. Genet Med. 2011 May;13(5):400-8 [PMID: 21270640]
  14. EBioMedicine. 2019 Oct;48:642-647 [PMID: 31597596]
  15. G3 (Bethesda). 2019 Nov 5;9(11):3791-3800 [PMID: 31690598]
  16. Nurse Educ. 2018 Jul/Aug;43(4):196-200 [PMID: 28858953]
  17. Genet Med. 2017 Jul;19(7):725-732 [PMID: 27763635]
  18. Front Microbiol. 2019 Jul 23;10:1533 [PMID: 31428059]
  19. Semin Fetal Neonatal Med. 2018 Apr;23(2):142-149 [PMID: 29233487]
  20. Genet Med. 2016 Jul;18(7):737-45 [PMID: 26583682]
  21. Am J Hum Genet. 2018 Jan 4;102(1):5-10 [PMID: 29304376]
  22. Genet Med. 2015 Aug;17(8):630-8 [PMID: 25503501]
  23. JAMA Oncol. 2015 Oct;1(7):943-51 [PMID: 26270727]
  24. J Genet Couns. 2019 Apr;28(2):466-476 [PMID: 30706981]
  25. J Microbiol Biol Educ. 2017 Jan 29;19(1): [PMID: 29904527]
  26. J Contin Educ Health Prof. 2016 Winter;36(1):82-5 [PMID: 26954250]
  27. JAMA. 2011 Sep 7;306(9):989-90 [PMID: 21900139]
  28. Hastings Cent Rep. 2019 May;49 Suppl 1:S88-S96 [PMID: 31268566]
  29. J Sch Health. 2014 Jun;84(6):351-4 [PMID: 24749916]
  30. Trends Genet. 2016 Jun;32(6):317-320 [PMID: 27117243]
  31. Annu Rev Genomics Hum Genet. 2014;15:507-16 [PMID: 24635717]
  32. PLoS One. 2014 Sep 05;9(9):e106744 [PMID: 25192356]
  33. J Genet Couns. 2014 Aug;23(4):679-88 [PMID: 24399091]
  34. J STEM Outreach. 2018 Apr;1(2):48-60 [PMID: 31667467]
  35. PLoS One. 2015 Aug 04;10(8):e0133486 [PMID: 26241308]
  36. F1000Res. 2019 Mar 1;8:241 [PMID: 31431825]
  37. Forensic Sci Int Genet. 2018 Sep;36:186-188 [PMID: 30041097]
  38. CBE Life Sci Educ. 2011 Fall;10(3):279-86 [PMID: 21885824]
  39. CBE Life Sci Educ. 2017 Summer;16(2): [PMID: 28408407]
  40. mBio. 2014 Feb 04;5(1):e01051-13 [PMID: 24496795]
  41. CBE Life Sci Educ. 2016 Summer;15(2): [PMID: 27146160]
  42. EMBO Rep. 2009 Feb;10(2):120-4 [PMID: 19165140]
  43. Microorganisms. 2019 Oct 16;7(10): [PMID: 31623075]
  44. J Cancer Epidemiol. 2012;2012:309109 [PMID: 22899921]
  45. BMC Med Genomics. 2018 Feb 13;11(1):18 [PMID: 29433521]
  46. Science. 2008 Oct 31;322(5902):684-5 [PMID: 18974335]
  47. Nat Biotechnol. 2009 Jun;27(6):514-8 [PMID: 19513051]
  48. Nurse Educ. 2018 Jul/Aug;43(4):201-205 [PMID: 28837438]
  49. PLoS One. 2018 Jul 6;13(7):e0200202 [PMID: 29979759]
  50. Acad Med. 2013 Aug;88(8):1088-94 [PMID: 23807109]
  51. Nurse Educ. 2016 Mar-Apr;41(2):86-9 [PMID: 26312820]
  52. Genet Med. 2014 Nov;16(11):804-9 [PMID: 24763287]
  53. PLoS One. 2018 Apr 11;13(4):e0193696 [PMID: 29641525]
  54. Soc Sci Med. 2014 Aug;114:26-37 [PMID: 24908172]
  55. CBE Life Sci Educ. 2018 Spring;17(1): [PMID: 29326101]
  56. PLoS One. 2013 Jul 23;8(7):e68853 [PMID: 23935898]
  57. Can Fam Physician. 2016 Oct;62(10):e626-e635 [PMID: 27737998]
  58. J Clin Oncol. 2017 Jul 10;35(20):2232-2239 [PMID: 28402748]
  59. Genome Res. 1999 Jul;9(7):597-607 [PMID: 10413399]
  60. J Genet Couns. 2014 Aug;23(4):445-51 [PMID: 24504939]
  61. JAMA. 1997 Oct 15;278(15):1285-6 [PMID: 9333274]
  62. Nature. 2015 Oct 15;526(7573):336-42 [PMID: 26469044]
  63. Gut Microbes. 2017 May 4;8(3):289-302 [PMID: 28001467]
  64. CBE Life Sci Educ. 2010 Spring;9(1):55-69 [PMID: 20194808]
  65. Curr Genet Med Rep. 2013 Sep;1(3):182-200 [PMID: 24058877]
  66. J Heart Lung Transplant. 2006 Dec;25(12):1389-95 [PMID: 17178330]
  67. Clin Transl Oncol. 2016 Oct;18(10):981-7 [PMID: 26742938]
  68. Science. 2019 Oct 11;366(6462):155 [PMID: 31601745]
  69. Psychiatr Clin North Am. 2011 Mar;34(1):147-66 [PMID: 21333845]
  70. CBE Life Sci Educ. 2014 Winter;13(4):711-23 [PMID: 25452493]
  71. Genet Med. 2014 Jul;16(7):516-21 [PMID: 24357847]
  72. PLoS One. 2016 Aug 29;11(8):e0161822 [PMID: 27571202]
  73. J Clin Oncol. 2009 Mar 20;27(9):1362-7 [PMID: 19224844]
  74. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13531-13536 [PMID: 29208718]
  75. Nurs Outlook. 2016 Jan-Feb;64(1):7-16 [PMID: 26813248]
  76. Nature. 2013 May 16;497(7449):287-8 [PMID: 23682397]
  77. Nurse Educ Today. 2018 Oct;69:53-59 [PMID: 30007148]
  78. Annu Rev Genomics Hum Genet. 2016 Aug 31;17:95-115 [PMID: 27362342]
  79. BMC Med Genomics. 2016 Oct 6;9(1):62 [PMID: 27716216]
  80. J Genet Couns. 2018 Feb;27(1):241-251 [PMID: 28879467]
  81. Biochem Mol Biol Educ. 2015 Jul-Aug;43(4):245-62 [PMID: 26148241]
  82. Genet Med. 2011 Jan;13(1):63-6 [PMID: 21057320]
  83. CBE Life Sci Educ. 2016 Summer;15(2): [PMID: 27252296]
  84. J Genet Couns. 2014 Aug;23(4):671-8 [PMID: 24584888]
  85. Am J Hum Genet. 2003 May;72(5):1117-30 [PMID: 12677558]
  86. J Nurs Scholarsh. 2013 Mar;45(1):96-104 [PMID: 23368636]
  87. J Nurs Educ. 2016 Oct 1;55(10):574-8 [PMID: 27668737]
  88. Hum Mol Genet. 2018 Aug 1;27(R2):R250-R258 [PMID: 29750248]

MeSH Term

Genetic Testing
Genome, Human
Genomics
Human Genetics
Humans
Precision Medicine

Word Cloud

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