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International journal of molecular sciences
Jan 28, 2020;21 (3):

Brain-Derived Neurotrophic Factor and Diabetes.

Olga Rozanska, Aleksandra Uruska, Dorota Zozulinska-Ziolkiewicz
Author Information
  1. Olga Rozanska: Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, ul. Mickiewicza 2, 60-834 Poznań, Poland.
  2. Aleksandra Uruska: Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, ul. Mickiewicza 2, 60-834 Poznań, Poland. ORCID
  3. Dorota Zozulinska-Ziolkiewicz: Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, ul. Mickiewicza 2, 60-834 Poznań, Poland. ORCID
PMID: 32012942 DOI: 10.3390/ijms21030841

Abstract

Diabetes and its chronic complications still represent a great clinical problem, despite improvements made in the diagnosis and treatment of the disease. People with diabetes have a much higher risk of impaired brain function and psychiatric disorders. Neurotrophins are factors that protect neuronal tissue and improve the function of the central nervous system, and among them is brain-derived neurotrophic factor (BDNF). The level and function of BDNF in diabetes seems to be disturbed by and connected with the presence of insulin resistance. On the other hand, there is evidence for the highly beneficial impact of physical activity on brain function and BDNF level. However, it is not clear if this protective phenomenon works in the presence of diabetes. In this review, we summarize the current available research on this topic and find that the results of published studies are ambiguous.

Keywords

brain-derived neurotrophic factor (BDNF) diabetes mellitus insulin resistance neuroprotection neurotrophins physical activity

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Grants

  1. Grant for Young Scientists/Poznan University of Medical Sciences

MeSH Term

Brain-Derived Neurotrophic Factor
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Gene Expression Regulation
Humans
Insulin Resistance
Nerve Growth Factors

Chemicals

Brain-Derived Neurotrophic Factor
Nerve Growth Factors
BDNF protein, human
Journal Article Review
Article has an altmetric score of 5

Word Cloud

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