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The Journal of experimental medicine
04 06, 2020;217 (4):

Tissue-specific pathways extrude activated ILC2s to disseminate type 2 immunity.

Roberto R Ricardo-Gonzalez, Christoph Schneider, Chang Liao, Jinwoo Lee, Hong-Erh Liang, Richard M Locksley
Author Information
  1. Roberto R Ricardo-Gonzalez: Department of Dermatology, University of California, San Francisco, San Francisco, CA.
  2. Christoph Schneider: Department of Medicine, University of California, San Francisco, San Francisco, CA.
  3. Chang Liao: Department of Medicine, University of California, San Francisco, San Francisco, CA.
  4. Jinwoo Lee: Department of Medicine, University of California, San Francisco, San Francisco, CA.
  5. Hong-Erh Liang: Department of Medicine, University of California, San Francisco, San Francisco, CA.
  6. Richard M Locksley: Department of Medicine, University of California, San Francisco, San Francisco, CA.
PMID: 32031571 DOI: 10.1084/jem.20191172

Abstract

Group 2 innate lymphoid cells (ILC2s) are tissue-resident cells prominent at barrier sites. Although precursors are found in blood, mature ILC2s can enter the circulation after small intestinal perturbation by migratory helminths and move to distant tissues to influence the local reparative response. Using fate-mapping and methods to bypass the lung or intestinal phases of Nippostrongylus brasiliensis infection, we show that blood ILC2s comprise heterogeneous populations derived from distinct tissues that are dependent on alarmins matched to the receptor profile of the specific tissue ILC2s. Activation of local ILC2s by tissue-specific alarmins induced their proliferation, lymph node migration, and blood dissemination, thus systemically distributing type 2 cytokines. These studies uncover a possible mechanism by which local innate responses transition to systemic type 2 responses by extrusion of activated sentinel ILC2s from tissue into the circulation.

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Grants

  1. T32 GM007618/NIGMS NIH HHS
  2. P01 HL107202/NHLBI NIH HHS
  3. F30 AI122702/NIAID NIH HHS
  4. K08 AR075880/NIAMS NIH HHS
  5. R01 AI026918/NIAID NIH HHS
  6. R01 HL128903/NHLBI NIH HHS
  7. /Howard Hughes Medical Institute

MeSH Term

Alarmins
Animals
Cell Movement
Cell Proliferation
Cytokines
Immunity, Innate
Lymph Nodes
Lymphocyte Activation
Lymphocytes
Mice
Mice, Inbred C57BL

Chemicals

Alarmins
Cytokines
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 5

Word Cloud

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