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Network neuroscience (Cambridge, Mass.)
2020;4 (1): 115-133.

Dynamic spatiotemporal patterns of brain connectivity reorganize across development.

Jakub Vohryzek, Alessandra Griffa, Emeline Mullier, Cecilia Friedrichs-Maeder, Corrado Sandini, Marie Schaer, Stephan Eliez, Patric Hagmann
Author Information
  1. Jakub Vohryzek: Department of Radiology, University Hospital Centre and University of Lausanne, Lausanne, Switzerland. ORCID
  2. Alessandra Griffa: Department of Radiology, University Hospital Centre and University of Lausanne, Lausanne, Switzerland.
  3. Emeline Mullier: Department of Radiology, University Hospital Centre and University of Lausanne, Lausanne, Switzerland.
  4. Cecilia Friedrichs-Maeder: Department of Radiology, University Hospital Centre and University of Lausanne, Lausanne, Switzerland.
  5. Corrado Sandini: Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland.
  6. Marie Schaer: Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland.
  7. Stephan Eliez: Department of Psychiatry, University of Geneva School of Medicine, Geneva, Switzerland.
  8. Patric Hagmann: Department of Radiology, University Hospital Centre and University of Lausanne, Lausanne, Switzerland.
PMID: 32043046 DOI: 10.1162/netn_a_00111

Abstract

Late human development is characterized by the maturation of high-level functional processes, which rely on reshaping of white matter connections, as well as synaptic density. However, the relationship between the whole-brain dynamics and the underlying white matter networks in neurodevelopment is largely unknown. In this study, we focused on how the structural connectome shapes the emerging dynamics of cerebral development between the ages of 6 and 33 years, using functional and diffusion magnetic resonance imaging combined into a spatiotemporal connectivity framework. We defined two new measures of brain dynamics, namely the system diversity and the spatiotemporal diversity, which quantify the level of integration/segregation between functional systems and the level of temporal self-similarity of the functional patterns of brain dynamics, respectively. We observed a global increase in system diversity and a global decrease and local refinement in spatiotemporal diversity values with age. In support of these findings, we further found an increase in the usage of long-range and inter-system white matter connectivity and a decrease in the usage of short-range connectivity with age. These findings suggest that dynamic functional patterns in the brain progressively become more integrative and temporally self-similar with age. These functional changes are supported by a greater involvement of long-range and inter-system axonal pathways.

Keywords

Brain dynamics Development Dynamic functional connectivity Spatiotemporal connectome Spatiotemporal diversity Structural connectivity System diversity

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Journal Article
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