OpenLB
Open Library of Bioscience
Advanced Search
International journal of molecular sciences
Feb 18, 2020;21 (4):

Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients.

Tamara Ovejero, Océane Sadones, Teresa Sánchez-Fito, Eloy Almenar-Pérez, José Andrés Espejo, Eva Martín-Martínez, Lubov Nathanson, Elisa Oltra
Author Information
  1. Tamara Ovejero: School of Medicine, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain.
  2. Océane Sadones: Université de Poitiers, CEDEX, 86073 Poitiers, France. ORCID
  3. Teresa Sánchez-Fito: Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, 46008 Valencia, Spain. ORCID
  4. Eloy Almenar-Pérez: Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, 46008 Valencia, Spain.
  5. José Andrés Espejo: School of Biotechnology, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain.
  6. Eva Martín-Martínez: National Health Service, Manises Hospital, 46940 Valencia, Spain.
  7. Lubov Nathanson: Institute for Neuro Immune Medicine, Nova Southeastern University, Ft Lauderdale, FL 33314, USA. ORCID
  8. Elisa Oltra: School of Medicine, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain. ORCID
PMID: 32085571 DOI: 10.3390/ijms21041366

Abstract

Advancements in nucleic acid sequencing technology combined with an unprecedented availability of metadata have revealed that 45% of the human genome constituted by transposable elements (TEs) is not only transcriptionally active but also physiologically necessary. Dysregulation of TEs, including human retroviral endogenous sequences (HERVs) has been shown to associate with several neurologic and autoimmune diseases, including Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). However, no study has yet addressed whether abnormal expression of these sequences correlates with fibromyalgia (FM), a disease frequently comorbid with ME/CFS. The work presented here shows, for the first time, that, in fact, HERVs of the H, K and W types are overexpressed in immune cells of FM patients with or without comorbid ME/CFS. Patients with increased HERV expression (N = 14) presented increased levels of interferon (INF-β and INF-γ) but unchanged levels of TNF-α. The findings reported in this study could explain the flu-like symptoms FM patients present with in clinical practice, in the absence of concomitant infections. Future work aimed at identifying specific genomic loci differentially affected in FM and/or ME/CFS is warranted.

Keywords

DNA methylation epigenetics fibromyalgia human endogenous retrovirus (HERV) interferon (INF) myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) non-Hodgkin’s lymphoma transfer RNA small fragments (tsRNAs) transposable elements

References

  1. Mol Cells. 2009 Aug 31;28(2):99-103 [PMID: 19669627]
  2. Pain. 2016 Nov;157(11):2493-2503 [PMID: 27429177]
  3. Int J Mol Sci. 2019 Aug 29;20(17): [PMID: 31470635]
  4. PLoS One. 2013 Oct 25;8(10):e78762 [PMID: 24205312]
  5. Mol Pain. 2019 Jan-Dec;15:1744806918819944 [PMID: 30486733]
  6. Curr Opin Rheumatol. 2017 Jul;29(4):355-360 [PMID: 28368979]
  7. Rev Med Virol. 2016 Mar;26(2):90-101 [PMID: 26643446]
  8. Pain. 2013 Jul;154(7):1045-56 [PMID: 23622762]
  9. J Rheumatol. 1991 May;18(5):728-33 [PMID: 1865419]
  10. Epigenomics. 2018 May;10(5):539-557 [PMID: 29692205]
  11. Lancet. 2016 Nov 19;388(10059):2476-2477 [PMID: 27751566]
  12. Nucleic Acids Res. 2016 Jan 4;44(D1):D81-9 [PMID: 26612867]
  13. J Vis Exp. 2009 Oct 29;(32): [PMID: 19865070]
  14. PLoS One. 2018 Jul 23;13(7):e0201066 [PMID: 30036399]
  15. BMC Musculoskelet Disord. 2019 Apr 9;20(1):156 [PMID: 30967132]
  16. Mol Cell. 2016 Jul 7;63(1):110-24 [PMID: 27345152]
  17. J Clin Pathol. 2014 Dec;67(12):1078-83 [PMID: 25240059]
  18. Noncoding RNA. 2019 Apr 24;5(2): [PMID: 31022830]
  19. Nucleic Acids Res. 2019 Mar 18;47(5):e27 [PMID: 30624635]
  20. Auto Immun Highlights. 2019 Nov 15;10(1):12 [PMID: 32257068]
  21. Rheumatol Int. 2015 Apr;35(4):635-42 [PMID: 25261961]
  22. Clin Ther. 2019 Apr;41(4):675-698 [PMID: 30910331]
  23. Med Care. 1993 Mar;31(3):247-63 [PMID: 8450681]
  24. RNA. 2017 Nov;23(11):1660-1671 [PMID: 28808124]
  25. Cancer. 2012 Dec 1;118(23):5929-36 [PMID: 22648858]
  26. Ann Intern Med. 1994 Dec 15;121(12):953-9 [PMID: 7978722]
  27. Retrovirology. 2006 Jul 06;3:44 [PMID: 16822326]
  28. J Pain. 2020 Jul - Aug;21(7-8):763-780 [PMID: 31837447]
  29. J Biol Chem. 2011 Sep 2;286(35):30253-30257 [PMID: 21757685]
  30. Mol Neurobiol. 2017 Nov;54(9):7129-7136 [PMID: 27796750]
  31. J Rheumatol. 1997 Dec;24(12):2273-5 [PMID: 9415626]
  32. PLoS One. 2015 Mar 24;10(3):e0121903 [PMID: 25803872]
  33. PLoS One. 2017 Feb 16;12(2):e0172415 [PMID: 28207850]
  34. Pain. 2017 Aug;158(8):1473-1480 [PMID: 28621701]
  35. Biochimie. 2007 Jun-Jul;89(6-7):761-9 [PMID: 17408842]
  36. BMJ Open. 2018 Sep 4;8(9):e020817 [PMID: 30181183]
  37. Front Neurol. 2019 Aug 20;10:894 [PMID: 31481926]
  38. Pharmaceutics. 2019 Mar 18;11(3): [PMID: 30889846]
  39. Neurosci Biobehav Rev. 2019 Dec;107:69-83 [PMID: 31465778]
  40. JAMA. 2015 Mar 17;313(11):1101-2 [PMID: 25668027]
  41. Arthritis Care Res (Hoboken). 2010 May;62(5):600-10 [PMID: 20461783]
  42. Clin Exp Rheumatol. 2007 Mar-Apr;25(2):225-30 [PMID: 17543146]
  43. Arch Toxicol. 2016 Oct;90(10):2405-19 [PMID: 27557899]
  44. J Intern Med. 2011 Oct;270(4):327-38 [PMID: 21777306]
  45. Yonsei Med J. 2010 Jan;51(1):9-17 [PMID: 20046508]
  46. J Psychosom Res. 1995 Apr;39(3):315-25 [PMID: 7636775]
  47. Semin Arthritis Rheum. 2016 Dec;46(3):319-329 [PMID: 27916278]
  48. Clin Exp Rheumatol. 2004 Sep-Oct;22(5):554-60 [PMID: 15485007]
  49. J Transl Med. 2018 Oct 1;16(1):268 [PMID: 30285773]
  50. J Dermatol Sci. 2015 Feb;77(2):110-6 [PMID: 25595738]
  51. Front Immunol. 2019 Jul 04;10:1525 [PMID: 31333659]
  52. J Immunol. 2007 May 1;178(9):5701-9 [PMID: 17442953]
  53. Ann Neurol. 2001 Oct;50(4):434-42 [PMID: 11601494]
  54. Clin Rheumatol. 2010 Feb;29(2):181-8 [PMID: 19898774]
  55. Oman Med J. 2012 May;27(3):192-5 [PMID: 22811766]
  56. Scand J Immunol. 2007 Dec;66(6):684-93 [PMID: 18021366]
  57. Arthritis Rheumatol. 2015 Feb;67(2):568-75 [PMID: 25323744]
  58. PLoS One. 2012;7(6):e40194 [PMID: 22761958]
  59. Bull NYU Hosp Jt Dis. 2011;69 Suppl 1:S56-61 [PMID: 22035487]
  60. Nat Methods. 2012 Jul;9(7):671-5 [PMID: 22930834]
  61. Mob Genet Elements. 2017 Nov 1;7(5):1-6 [PMID: 29201533]
  62. Bioinformatics. 2015 Nov 15;31(22):3593-9 [PMID: 26206304]
  63. J Transl Med. 2019 Jun 28;17(1):213 [PMID: 31253154]
  64. Clin Sci (Lond). 2018 Mar 9;132(5):523-542 [PMID: 29523751]
  65. Am J Phys Med Rehabil. 2015 Dec;94(12):1075-82 [PMID: 25888651]
  66. Nurs Res Pract. 2013;2013:795784 [PMID: 24058735]

Grants

  1. 2018-121-001/Universidad Católica de Valencia San Vicente Mártir

MeSH Term

Adult
Aged
Cytokines
DNA Transposable Elements
Endogenous Retroviruses
Fatigue
Female
Fibromyalgia
Humans
Leukocytes
Linear Models
Male
Middle Aged
Models, Biological
RNA, Transfer
Surveys and Questionnaires

Chemicals

Cytokines
DNA Transposable Elements
RNA, Transfer
Journal Article
Article has an altmetric score of 47

Word Cloud

Created with Highcharts 10.0.0ME/CFSFMhumantransposableelementsTEsincludingendogenoussequencesHERVsstudyexpressionfibromyalgiacomorbidworkpresentedpatientsPatientsincreasedHERVlevelsinterferonAdvancementsnucleicacidsequencingtechnologycombinedunprecedentedavailabilitymetadatarevealed45%genomeconstitutedtranscriptionallyactivealsophysiologicallynecessaryDysregulationretroviralshownassociateseveralneurologicautoimmunediseasesMyalgicEncephalomyelitis/ChronicFatigueSyndromeHoweveryetaddressedwhetherabnormalcorrelatesdiseasefrequentlyshowsfirsttimefactHKWtypesoverexpressedimmunecellswithoutN=14INF-βINF-γunchangedTNF-αfindingsreportedexplainflu-likesymptomspresentclinicalpracticeabsenceconcomitantinfectionsFutureaimedidentifyingspecificgenomiclocidifferentiallyaffectedand/orwarrantedActivationTransposableElementsImmuneCellsFibromyalgiaDNAmethylationepigeneticsretrovirusINFmyalgicencephalomyelitis/chronicfatiguesyndromenon-Hodgkin’slymphomatransferRNAsmallfragmentstsRNAs

Similar Articles

Cited By