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Pathogens (Basel, Switzerland)
Feb 25, 2020;9 (3):

C: An Expanding Species of Emerging Hepatitis E Virus Variants.

Bo Wang, Dominik Harms, Xing-Lou Yang, C-Thomas Bock
Author Information
  1. Bo Wang: Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
  2. Dominik Harms: Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, 13353 Berlin, Germany.
  3. Xing-Lou Yang: CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
  4. C-Thomas Bock: Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, 13353 Berlin, Germany.
PMID: 32106525 DOI: 10.3390/pathogens9030154

Abstract

Hepatitis E virus (HEV) is an emerging zoonotic pathogen that has received an increasing amount of attention from virologists, clinicians, veterinarians, and epidemiologists over the past decade. The host range and animal reservoirs of HEV are rapidly expanding and a plethora of emerging HEV variants have been recently identified, some of which have the potential for interspecies infection. In this review, the detection of genetically diverse HEV variants, classified into and presumably associated with the species C, currently comprising HEV genotypes C1 and C2, by either serological or molecular approach is summarized. The distribution, genomic variability, and evolution of C are analyzed. Moreover, the potential risk of cross-species infection and zoonotic transmission of C are discussed.

Keywords

Orthohepevirus C genetic variability hepatitis E virus host molecular evolution zoonosis

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Grants

  1. CHED-project grant No: ZMVI1-2516-AUK-701 / BMG: 321-4471-02/157/German Federal Ministry of Health
  2. Dissertation Plus/Claussen-Simon-Stiftung
  3. Dissertation Scholar ship/China Scholarship Council
  4. Promotionsstipendium/FAZIT Stiftung
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Created with Highcharts 10.0.0HEVCEHepatitisvirusemergingzoonotichostvariantspotentialinfectionmolecularvariabilityevolutionpathogenreceivedincreasingamountattentionvirologistscliniciansveterinariansepidemiologistspastdecaderangeanimalreservoirsrapidlyexpandingplethorarecentlyidentifiedinterspeciesreviewdetectiongeneticallydiverseclassifiedpresumablyassociatedspeciescurrentlycomprisinggenotypesC1C2eitherserologicalapproachsummarizeddistributiongenomicanalyzedMoreoverriskcross-speciestransmissiondiscussedC:ExpandingSpeciesEmergingVirusVariantsOrthohepevirusgenetichepatitiszoonosis

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