Near-Infrared Light Triggered-Release in Deep Brain Regions Using Ultra-photosensitive Nanovesicles.
Hejian Xiong, Xiuying Li, Peiyuan Kang, John Perish, Frederik Neuhaus, Jonathan E Ploski, Sven Kroener, Maria O Ogunyankin, Jeong Eun Shin, Joseph A Zasadzinski, Hui Wang, Paul A Slesinger, Andreas Zumbuehl, Zhenpeng Qin
Author Information
Hejian Xiong: Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX, 75080, USA. ORCID
Xiuying Li: Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX, 75080, USA.
Peiyuan Kang: Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX, 75080, USA.
John Perish: School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, 75080, USA.
Frederik Neuhaus: National Centre of Competence in Research in Chemical Biology, 30 quai Ernest Ansermet, 1211, Geneva 4, Switzerland.
Jonathan E Ploski: School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, 75080, USA.
Sven Kroener: School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, 75080, USA.
Maria O Ogunyankin: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, 55455, USA.
Jeong Eun Shin: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, 55455, USA.
Joseph A Zasadzinski: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, 55455, USA.
Hui Wang: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, 02129, USA.
Paul A Slesinger: Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-5674, USA.
Andreas Zumbuehl: Acthera Therapeutics Ltd., Peter Merian-Str. 45, 4052, Basel, Switzerland.
Zhenpeng Qin: Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TX, 75080, USA. ORCID
Remote and minimally-invasive modulation of biological systems with light has transformed modern biology and neuroscience. However, light absorption and scattering significantly prevents penetration to deep brain regions. Herein, we describe the use of gold-coated mechanoresponsive nanovesicles, which consist of liposomes made from the artificial phospholipid Rad-PC-Rad as a tool for the delivery of bioactive molecules into brain tissue. Near-infrared picosecond laser pulses activated the gold-coating on the surface of nanovesicles, creating nanomechanical stress and leading to near-complete vesicle cargo release in sub-seconds. Compared to natural phospholipid liposomes, the photo-release was possible at 40 times lower laser energy. This high photosensitivity enables photorelease of molecules down to a depth of 4 mm in mouse brain. This promising tool provides a versatile platform to optically release functional molecules to modulate brain circuits.
