Presence and Concentrations of Select Bacterial Vaginosis-Associated Bacteria Are Associated With Increased Risk of Pelvic Inflammatory Disease.

Catherine L Haggerty, Roberta B Ness, Patricia A Totten, Fouzia Farooq, Gong Tang, Daisy Ko, Xuezhou Hou, Tina L Fiedler, Sujatha Srinivasan, Sabina G Astete, David N Fredricks
Author Information
  1. Catherine L Haggerty: From the Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
  2. Roberta B Ness: The University of Texas School of Public Health, Houston, TX.
  3. Patricia A Totten: Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA.
  4. Fouzia Farooq: From the Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
  5. Gong Tang: Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
  6. Daisy Ko: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
  7. Xuezhou Hou: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
  8. Tina L Fiedler: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
  9. Sujatha Srinivasan: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
  10. Sabina G Astete: Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA.
  11. David N Fredricks: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA.

Abstract

In a vaginal 16S ribosomal RNA gene quantitative PCR study of 17 pelvic inflammatory disease (PID) cases and 17 controls who tested positive for Chlamydia trachomatis, women who additionally tested positive for Atopobium vaginae, Sneathia spp., Megasphaera spp., Eggerthella-like bacterium or Prevotella amnii were more likely to develop PID.

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Grants

  1. R56 AI139189/NIAID NIH HHS
  2. T32 HL083825/NHLBI NIH HHS

MeSH Term

Actinobacteria
Adult
Anti-Bacterial Agents
Bacteria
Case-Control Studies
DNA, Bacterial
DNA, Ribosomal
Female
Humans
Pelvic Inflammatory Disease
Polymerase Chain Reaction
Prevotella
RNA, Ribosomal, 16S
Vagina
Vaginosis, Bacterial

Chemicals

Anti-Bacterial Agents
DNA, Bacterial
DNA, Ribosomal
RNA, Ribosomal, 16S

Word Cloud

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