Genetic evolution analysis of 2019 novel coronavirus and coronavirus from other species.

Chun Li, Yanling Yang, Linzhu Ren
Author Information
  1. Chun Li: The Chinese Peoples' Liberation Army 964 Hospital, Changchun, China.
  2. Yanling Yang: Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China. Electronic address: m18043213639@163.com.
  3. Linzhu Ren: College of Animal Sciences, Jilin University, Changchun 130062, China. Electronic address: renlz@jlu.edu.cn.

Abstract

The Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a Public Health Emergency of International Concern. However, so far, there are still controversies about the source of the virus and its intermediate host. Here, we found the novel coronavirus was closely related to coronaviruses derived from five wild animals, including Paguma larvata, Paradoxurus hermaphroditus, Civet, Aselliscus stoliczkanus and Rhinolophus sinicus, and was in the same branch of the phylogenetic tree. However, genome and ORF1a homology show that the virus is not the same coronavirus as the coronavirus derived from these five animals, whereas the virus has the highest homology with Bat coronavirus isolate RaTG13.

Keywords

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MeSH Term

Animals
Betacoronavirus
Chiroptera
Coronavirus
Evolution, Molecular
Mammals
Mutation
Phylogeny
RNA, Viral
SARS-CoV-2
Sequence Homology, Nucleic Acid

Chemicals

RNA, Viral

Word Cloud

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