- Ana V Cheng: Department of Chemistry, Emory University, 1515 Dickey Dr., Atlanta, GA 30322, USA.
- William M Wuest: Department of Chemistry, Emory University, 1515 Dickey Dr., Atlanta, GA 30322, USA. Electronic address: wwuest@emory.edu.
Bacteria are extremely adept at overcoming the effects of antibiotics through a variety of mechanisms. As a result, researchers are constantly searching for antibiotics with new mechanisms of action. Culp and coworkers recently utilized a phylogeny-guided approach to mine the genomes of Actinomycetes species for glycopeptides with novel targets. Their efforts yielded the identification of complestatin and corbomycin as antibiotics with a different target than other glycopeptides.