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04 23, 2020;10 (1): 6873.

Bat coronavirus phylogeography in the Western Indian Ocean.

Léa Joffrin, Steven M Goodman, David A Wilkinson, Beza Ramasindrazana, Erwan Lagadec, Yann Gomard, Gildas Le Minter, Andréa Dos Santos, M Corrie Schoeman, Rajendraprasad Sookhareea, Pablo Tortosa, Simon Julienne, Eduardo S Gudo, Patrick Mavingui, Camille Lebarbenchon
Author Information
  1. Léa Joffrin: Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, Sainte-Clotilde, La Réunion, France. lea.joffrin@gmail.com.
  2. Steven M Goodman: Association Vahatra, Antananarivo, Madagascar.
  3. David A Wilkinson: Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, Sainte-Clotilde, La Réunion, France.
  4. Beza Ramasindrazana: Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, Sainte-Clotilde, La Réunion, France.
  5. Erwan Lagadec: Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, Sainte-Clotilde, La Réunion, France.
  6. Yann Gomard: Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, Sainte-Clotilde, La Réunion, France.
  7. Gildas Le Minter: Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, Sainte-Clotilde, La Réunion, France.
  8. Andréa Dos Santos: Veterinary Faculty, Eduardo Mondlane University, Maputo, Mozambique.
  9. M Corrie Schoeman: School of Life Sciences, University of Kwa-Zulu Natal, Kwa-Zulu Natal, South Africa.
  10. Rajendraprasad Sookhareea: National Parks and Conservation Service, Réduit, Mauritius.
  11. Pablo Tortosa: Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, Sainte-Clotilde, La Réunion, France.
  12. Simon Julienne: Seychelles Ministry of Health, Victoria, Mahe, Seychelles.
  13. Eduardo S Gudo: Instituto Nacional de Saúde, Maputo, Mozambique.
  14. Patrick Mavingui: Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, Sainte-Clotilde, La Réunion, France.
  15. Camille Lebarbenchon: Université de La Réunion, UMR Processus Infectieux en Milieu Insulaire Tropical (PIMIT), INSERM 1187, CNRS 9192, IRD 249, Sainte-Clotilde, La Réunion, France. camille.lebarbenchon@univ-reunion.fr.
PMID: 32327721 DOI: 10.1038/s41598-020-63799-7

Abstract

Bats provide key ecosystem services such as crop pest regulation, pollination, seed dispersal, and soil fertilization. Bats are also major hosts for biological agents responsible for zoonoses, such as coronaviruses (CoVs). The islands of the Western Indian Ocean are identified as a major biodiversity hotspot, with more than 50 bat species. In this study, we tested 1,013 bats belonging to 36 species from Mozambique, Madagascar, Mauritius, Mayotte, Reunion Island and Seychelles, based on molecular screening and partial sequencing of the RNA-dependent RNA polymerase gene. In total, 88 bats (8.7%) tested positive for coronaviruses, with higher prevalence in Mozambican bats (20.5% ± 4.9%) as compared to those sampled on islands (4.5% ± 1.5%). Phylogenetic analyses revealed a large diversity of α- and β-CoVs and a strong signal of co-evolution between CoVs and their bat host species, with limited evidence for host-switching, except for bat species sharing day roost sites. These results highlight that strong variation between islands does exist and is associated with the composition of the bat species community on each island. Future studies should investigate whether CoVs detected in these bats have a potential for spillover in other hosts.

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MeSH Term

Alphacoronavirus
Animals
Base Sequence
Betacoronavirus
Chiroptera
Coronavirus Infections
DNA, Viral
Ecosystem
Evolution, Molecular
Genetic Variation
Host Specificity
Indian Ocean Islands
Phylogeny
Phylogeography
Prevalence
RNA-Dependent RNA Polymerase
Real-Time Polymerase Chain Reaction
Zoonoses

Chemicals

DNA, Viral
RNA-Dependent RNA Polymerase
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 295

Word Cloud

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