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May 08, 2020;10 (5):

Event-Related Potentials (ERP) Indices of Motivation during the Effort Expenditure for Reward Task.

Julie Giustiniani, Magali Nicolier, Juliana Teti Mayer, Thibault Chabin, Caroline Masse, Nathan Galmès, Lionel Pazart, Benoit Trojak, Djamila Bennabi, Pierre Vandel, Emmanuel Haffen, Damien Gabriel
Author Information
  1. Julie Giustiniani: Department of Clinical Psychiatry, University Hospital of Besançon, 25000 Besançon, France. ORCID
  2. Magali Nicolier: Department of Clinical Psychiatry, University Hospital of Besançon, 25000 Besançon, France.
  3. Juliana Teti Mayer: Department of Clinical Psychiatry, University Hospital of Besançon, 25000 Besançon, France. ORCID
  4. Thibault Chabin: EA 481, Laboratory of Neurosciences, University of Burgundy Franche-Comté, 25000 Besançon, France.
  5. Caroline Masse: Department of Clinical Psychiatry, University Hospital of Besançon, 25000 Besançon, France.
  6. Nathan Galmès: EA 481, Laboratory of Neurosciences, University of Burgundy Franche-Comté, 25000 Besançon, France.
  7. Lionel Pazart: EA 481, Laboratory of Neurosciences, University of Burgundy Franche-Comté, 25000 Besançon, France.
  8. Benoit Trojak: Department of Psychiatry and Addictology, University Hospital of Dijon, 21079 Dijon, France.
  9. Djamila Bennabi: Department of Clinical Psychiatry, University Hospital of Besançon, 25000 Besançon, France.
  10. Pierre Vandel: Department of Clinical Psychiatry, University Hospital of Besançon, 25000 Besançon, France.
  11. Emmanuel Haffen: Department of Clinical Psychiatry, University Hospital of Besançon, 25000 Besançon, France. ORCID
  12. Damien Gabriel: EA 481, Laboratory of Neurosciences, University of Burgundy Franche-Comté, 25000 Besançon, France. ORCID
PMID: 32397250 DOI: 10.3390/brainsci10050283

Abstract

Dynamic and temporal facets of the various constructs that comprise motivation remain to be explored. Here, we adapted the Effort Expenditure for Reward Task, a well-known laboratory task used to evaluate motivation, to study the event-related potentials associated with reward processing. The Stimulus Preceding Negativity (SPN) and the P300 were utilized as motivation indicators with high density electroencephalography. The SPN was found to be more negative for difficult choices compared to easy choices, suggesting a greater level of motivation, at a neurophysiological level. The insula, a structure previously associated with both effort discounting and prediction error, was concomitantly activated during the generation of the SPN. Processing a gain significantly altered the amplitude of the P300 compared to an absence of gain, particularly on centroparietal electrodes. One of the generators of the P300 was located on the vmPFC, a cerebral structure involved in the choice between two positive results and their predictions, during loss processing. Both the SPN and the P300 appear to be reliable neural markers of motivation. We postulate that the SPN represents the strength of the motivational level, while the P300 represents the impact of motivation on updating memories of the feedback.

Keywords

EEfRT P300 SPN effort motivation

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