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Neurology
05 26, 2020;94 (21): e2245-e2257.

Aerobic exercise improves cognition and cerebrovascular regulation in older adults.

Veronica Guadagni, Lauren L Drogos, Amanda V Tyndall, Margie H Davenport, Todd J Anderson, Gail A Eskes, R Stewart Longman, Michael D Hill, David B Hogan, Marc J Poulin
Author Information
  1. Veronica Guadagni: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada. ORCID
  2. Lauren L Drogos: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
  3. Amanda V Tyndall: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
  4. Margie H Davenport: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
  5. Todd J Anderson: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
  6. Gail A Eskes: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
  7. R Stewart Longman: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
  8. Michael D Hill: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada. ORCID
  9. David B Hogan: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada.
  10. Marc J Poulin: From the Department of Physiology and Pharmacology (V.G., L.L.D., A.V.T., G.A.E., M.J.P.), Hotchkiss Brain Institute (V.G., L.L.D., A.V.T., R.S.L., M.D.H., D.B.H., M.J.P.), Division of Geriatric Medicine (D.B.H.), Department of Medicine, Department of Clinical Neurosciences (V.G., L.L.D., A.V.T., M.D.H., D.B.H., M.J.P.), Libin Cardiovascular Institute of Alberta (T.J.A., M.J.P.), O'Brien Institute for Public Health (V.G., D.B.H., M.J.P.), Department of Cardiac Sciences (T.J.A.), Libin Cardiovascular Institute of Alberta, and Department of Community Health Sciences (M.D.H.), Cumming School of Medicine, Faculty of Kinesiology (M.J.P.), and Department of Psychology (R.S.L.), University of Calgary; Psychology Service (R.S.L.), Alberta Health Service, Foothills Medical Centre, Calgary; Department of Psychiatry (G.A.E.), Faculty of Medicine, and Department of Psychology and Neuroscience (G.A.E.), Faculty of Science, Dalhousie University, Halifax, Nova Scotia; and Program for Pregnancy and Postpartum Health, Physical Activity and Diabetes Laboratory (M.H.D.), Faculty of Kinesiology, Sport, and Recreation, Women and Children's Health Research Institute, Alberta Diabetes Institute, University of Alberta, Edmonton, Canada. poulin@ucalgary.ca.
PMID: 32404355 DOI: 10.1212/WNL.0000000000009478

Abstract

OBJECTIVE: To test the hypothesis that aerobic exercise is associated with improvements in cognition and cerebrovascular regulation, we enrolled 206 healthy low-active middle-aged and older adults (mean ± SD age 65.9 ± 6.4 years) in a supervised 6-month aerobic exercise intervention and assessed them before and after the intervention.
METHODS: The study is a quasi-experimental single group pre/postintervention study. Neuropsychological tests were used to assess cognition before and after the intervention. Transcranial Doppler ultrasound was used to measure cerebral blood flow velocity. Cerebrovascular regulation was assessed at rest, during euoxic hypercapnia, and in response to submaximal exercise. Multiple linear regression was used to examine the association between changes in cognition and changes in cerebrovascular function.
RESULTS: The intervention was associated with improvements in some cognitive domains, cardiorespiratory fitness, and cerebrovascular regulation. Changes in executive functions were negatively associated with changes in cerebrovascular resistance index (CVRi) during submaximal exercise (β = -0.205, = 0.013), while fluency improvements were positively associated with changes in CVRi during hypercapnia (β = 0.106, 0.03).
CONCLUSION: The 6-month aerobic exercise intervention was associated with improvements in some cognitive domains and cerebrovascular regulation. Secondary analyses showed a novel association between changes in cognition and changes in cerebrovascular regulation during euoxic hypercapnia and in response to submaximal exercise.

References

  1. J Appl Physiol (1985). 2007 Mar;102(3):870-7 [PMID: 17110510]
  2. Exerc Sport Sci Rev. 2012 Jul;40(3):153-8 [PMID: 22504726]
  3. J Alzheimers Dis. 2019;67(2):671-684 [PMID: 30636734]
  4. J Appl Physiol (1985). 1998 Aug;85(2):388-97 [PMID: 9688710]
  5. Front Aging Neurosci. 2013 Nov 12;5:75 [PMID: 24282403]
  6. J Appl Physiol (1985). 2004 Jul;97(1):149-59 [PMID: 15004003]
  7. Exerc Sport Sci Rev. 2018 Oct;46(4):215-223 [PMID: 30001269]
  8. J Alzheimers Dis. 2019;68(1):39-64 [PMID: 30776004]
  9. J Appl Physiol (1985). 2009 Nov;107(5):1370-80 [PMID: 19729591]
  10. Hum Brain Mapp. 2013 Nov;34(11):2972-85 [PMID: 22674729]
  11. JAMA. 2015 Aug 25;314(8):781-90 [PMID: 26305648]
  12. Curr Sports Med Rep. 2013 Jul-Aug;12(4):215-7 [PMID: 23851406]
  13. J Neurosurg. 1982 Dec;57(6):769-74 [PMID: 7143059]
  14. Prog Neurobiol. 2010 Oct;92(2):134-50 [PMID: 20542078]
  15. Physiol Rev. 1955 Oct;35(4):801-40 [PMID: 13266530]
  16. Exp Physiol. 2017 Nov 1;102(11):1356-1371 [PMID: 28786150]
  17. Med Sci Sports Exerc. 1994 Jan;26(1):103-7 [PMID: 8133729]
  18. J Appl Physiol (1985). 1999 May;86(5):1632-7 [PMID: 10233128]
  19. J Int Neuropsychol Soc. 2015 Nov;21(10):816-30 [PMID: 26581793]
  20. Multivariate Behav Res. 1989 Jan 1;24(1):59-69 [PMID: 26794296]
  21. BMC Neurosci. 2014 Jan 24;15:19 [PMID: 24456150]
  22. Neurotherapeutics. 2019 Jul;16(3):580-599 [PMID: 31197642]
  23. Neurology. 2011 Sep 27;77(13):1272-5 [PMID: 21917776]
  24. J Appl Physiol (1985). 1998 Aug;85(2):386-7 [PMID: 9688709]
  25. J Appl Physiol (1985). 1996 Sep;81(3):1084-95 [PMID: 8889738]
  26. Neuropsychol Rev. 2014 Sep;24(3):355-70 [PMID: 25143069]
  27. Age (Dordr). 2013 Jun;35(3):905-20 [PMID: 22669592]
  28. J Alzheimers Dis. 2019;68(3):961-968 [PMID: 30814346]
  29. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3316-21 [PMID: 14978288]
  30. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2029-34 [PMID: 11172070]
  31. Nat Rev Cardiol. 2018 Sep;15(9):555-565 [PMID: 29795441]
  32. J Ultrasound Med. 2010 Jul;29(7):1017-22 [PMID: 20587424]
  33. Microvasc Res. 1989 Mar;37(2):230-6 [PMID: 2725343]
  34. Alzheimers Dement (Amst). 2015 Mar 29;1(1):101-2 [PMID: 27239496]
  35. Neuroimage. 2006 Apr 15;30(3):1038-49 [PMID: 16414280]
  36. Clin Interv Aging. 2018 Jul 20;13:1267-1301 [PMID: 30057444]
  37. Trends Neurosci. 2009 May;32(5):283-90 [PMID: 19349082]
  38. Nat Rev Cardiol. 2018 Sep;15(9):566-577 [PMID: 29795242]
  39. Neuropsychiatry Neuropsychol Behav Neurol. 1997 Apr;10(2):144-6 [PMID: 9150516]
  40. BMC Neurosci. 2010 Sep 16;11:118 [PMID: 20846444]
  41. Neurobiol Aging. 2010 Dec;31(12):2047-57 [PMID: 19111937]
  42. Neuroimage. 2008 May 1;40(4):1824-32 [PMID: 18343687]
  43. Arch Clin Neuropsychol. 2016 Feb;31(1):47-57 [PMID: 26645315]
  44. Arch Intern Med. 2010 Jan 25;170(2):170-8 [PMID: 20101012]
  45. PLoS One. 2015 Nov 23;10(11):e0143059 [PMID: 26599343]
  46. Nat Neurosci. 2018 Oct;21(10):1318-1331 [PMID: 30250261]
  47. BMC Geriatr. 2013 Feb 28;13:21 [PMID: 23448504]

Grants

  1. MOP 142470/CIHR

MeSH Term

Aged
Cerebrovascular Circulation
Cognition
Executive Function
Exercise
Female
Healthy Volunteers
Humans
Hypercapnia
Male
Memory
Neuropsychological Tests
Oxygen Consumption
Physical Fitness
Ultrasonography, Doppler, Transcranial
Clinical Trial Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 437

Word Cloud

Created with Highcharts 10.0.0exercisecerebrovascularregulationchangesassociatedcognitioninterventionimprovementsaerobicusedhypercapniasubmaximal=0olderadults±6-monthassessedstudyeuoxicresponseassociationcognitivedomainsCVRiβOBJECTIVE:testhypothesisenrolled206healthylow-activemiddle-agedmeanSDage65964yearssupervisedMETHODS:quasi-experimentalsinglegrouppre/postinterventionNeuropsychologicaltestsassessTranscranialDopplerultrasoundmeasurecerebralbloodflowvelocityCerebrovascularrestMultiplelinearregressionexaminefunctionRESULTS:cardiorespiratoryfitnessChangesexecutivefunctionsnegativelyresistanceindex-0205013fluencypositively10603CONCLUSION:SecondaryanalysesshowednovelAerobicimproves

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