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Mycotoxin research
Aug, 2020;36 (3): 319-326.

Effects of trichothecene mycotoxin T-2 toxin on haematological and immunological parameters of rainbow trout (Oncorhynchus mykiss).

Helena Modra, Miroslava Palikova, Pavel Hyrsl, Jana Bartonkova, Ivana Papezikova, Zdenka Svobodova, Jana Blahova, Jan Mares
Author Information
  1. Helena Modra: Department of Zoology, Fisheries, Hydrobiology and Apiculture, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00, Brno, Czech Republic. helena.modra@mendelu.cz. ORCID
  2. Miroslava Palikova: Department of Zoology, Fisheries, Hydrobiology and Apiculture, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00, Brno, Czech Republic. ORCID
  3. Pavel Hyrsl: Department of Experimental Biology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37, Brno, Czech Republic. ORCID
  4. Jana Bartonkova: Department of Experimental Biology, Faculty of Science, Masaryk University, Kotlarska 2, 611 37, Brno, Czech Republic.
  5. Ivana Papezikova: Department of Zoology, Fisheries, Hydrobiology and Apiculture, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00, Brno, Czech Republic. ORCID
  6. Zdenka Svobodova: Department of Animal Protection, Welfare and Behaviour, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1946/1, 612 42, Brno, Czech Republic.
  7. Jana Blahova: Department of Animal Protection, Welfare and Behaviour, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho tr. 1946/1, 612 42, Brno, Czech Republic.
  8. Jan Mares: Department of Zoology, Fisheries, Hydrobiology and Apiculture, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00, Brno, Czech Republic. ORCID
PMID: 32451776 DOI: 10.1007/s12550-020-00396-7

Abstract

The aim of this study was to assess the effects of T-2 toxin-contaminated feed (at concentrations of 1.0 and 1.8 mg/kg) on the rainbow trout immune system by studying non-specific cellular and humoral immune responses and its effect on red and white blood cells. Consumption of T-2 toxin at both concentrations resulted in significantly increased erythrocyte counts and a decrease in mean corpuscular volume. While a significant decrease in mean corpuscular haemoglobin was observed at both experimental concentrations, the decrease in plasma haemoglobin was only significant at the higher T-2 toxin concentration. Higher T-2 toxin concentrations resulted in a significant increase in leukocyte and lymphocyte count, while absolute phagocyte count and counts of less mature neutrophil granulocyte forms remained unchanged at both concentrations. Non-specific humoral immunity (bactericidal activity measured as complement activation) decreased significantly in both experimental groups when compared with the control. The results of this study show that T-2 toxin in feed at a concentration range of 1.0-1.8 mg/kg influences the immunological defence mechanisms of rainbow trout.Trial registration number, MSMT-3876/2014-14; date of registration, 31/1/2014.

Keywords

Deoxynivalenol Erythropoiesis Fungi Fusarium Immunoglobulins

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Grants

  1. CZ.02.1.01/0.0/0.0/16_019/0000869/Ministerstvo Školství, Mládeže a Tělovýchovy

MeSH Term

Animal Feed
Animals
Erythrocyte Count
Food Contamination
Fusarium
Hemoglobins
Immunity, Humoral
Leukocyte Count
Oncorhynchus mykiss
T-2 Toxin

Chemicals

Hemoglobins
T-2 Toxin
Journal Article
Article has an altmetric score of 1

Word Cloud

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