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Obesity (Silver Spring, Md.)
07, 2020;28 (7): 1283-1291.

Abnormal Regional Neural Activity and Reorganized Neural Network in Obesity: Evidence from Resting-State fMRI.

Peng Zhang, Guo-Wei Wu, Feng-Xia Yu, Yang Liu, Meng-Yi Li, Zheng Wang, He-Yu Ding, Xiao-Shuai Li, Hao Wang, Mei Jin, Zheng-Yu Zhang, Peng-Fei Zhao, Jing Li, Zheng-Han Yang, Han Lv, Zhong-Tao Zhang, Zhen-Chang Wang
Author Information
  1. Peng Zhang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  2. Guo-Wei Wu: School of Language Science and Art, Jiang Su Normal University, Xuzhou, China.
  3. Feng-Xia Yu: Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
  4. Yang Liu: Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, Beijing, China.
  5. Meng-Yi Li: Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, Beijing, China.
  6. Zheng Wang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  7. He-Yu Ding: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  8. Xiao-Shuai Li: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  9. Hao Wang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  10. Mei Jin: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  11. Zheng-Yu Zhang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  12. Peng-Fei Zhao: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  13. Jing Li: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  14. Zheng-Han Yang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  15. Han Lv: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. ORCID
  16. Zhong-Tao Zhang: Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, Beijing, China. ORCID
  17. Zhen-Chang Wang: Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. ORCID
PMID: 32510870 DOI: 10.1002/oby.22839

Abstract

OBJECTIVE: This study aimed to investigate regional neural activity and regulation of patterns in the reorganized neural network of obesity and explore the correlation between brain activities and eating behavior.
METHODS: A total of 23 individuals with obesity and 23 controls with normal weight were enrolled. Functional magnetic resonance imaging (fMRI) data were acquired using 3.0-T MRI. Amplitude of low-frequency fluctuation and functional connectivity (FC) analyses were conducted using Data Processing Assistant for resting-state fMRI and Resting-State fMRI Data Analysis Toolkit (REST).
RESULTS: The group with obesity showed increased amplitude of low-frequency values in left fusiform gyrus/amygdala, inferior temporal gyrus (ITG), hippocampus/parahippocampal gyrus, and bilateral caudate but decreased values in right superior temporal gyrus. The group with obesity showed increased FC between left caudate and right superior temporal gyrus, left fusiform gyrus/amygdala and left ITG, right caudate and left fusiform gyrus/amygdala, and right caudate and left hippocampus/parahippocampal gyrus. Dutch Eating Behavior Questionnaire-Emotional scores were positively correlated with FC between left hippocampus/parahippocampal gyrus and right caudate but negatively correlated with FC between left fusiform gyrus/amygdala and left ITG.
CONCLUSIONS: The study indicated the reorganized neural network presented as a bilateral cross-regulation pattern across hemispheres between reward and various appetite-related functional processing, thus affecting emotional and external eating behavior. These results could provide further evidence for neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential in obesity.

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Grants

  1. [2015] 160/Beijing Scholars Program
  2. PX2018001/Beijing Municipal Administration of Hospitals
  3. QML20180103/Beijing Municipal Administration of Hospitals
  4. 61527807/National Natural Science Foundation of China
  5. 61801311/National Natural Science Foundation of China
  6. 81701644/National Natural Science Foundation of China
  7. YYZZ2017B01/seed project
  8. YYZZ201917/seed project
  9. SML20150101/Beijing Municipal Administration of Hospital' Mission Plan
  10. 7162048/Natural Science Foundation of Beijing Municipality
  11. 7172064/Natural Science Foundation of Beijing Municipality
  12. 7182044/Natural Science Foundation of Beijing Municipality

MeSH Term

Adolescent
Adult
Appetite Regulation
Brain
Brain Mapping
Case-Control Studies
Feeding Behavior
Feeding and Eating Disorders
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nerve Net
Obesity
Rest
Young Adult
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 2

Word Cloud

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