Dried fruit consumption and cardiometabolic health: a randomised crossover trial.

Valerie K Sullivan, Kristina S Petersen, Penny M Kris-Etherton
Author Information
  1. Valerie K Sullivan: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA16802, USA. ORCID
  2. Kristina S Petersen: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA16802, USA. ORCID
  3. Penny M Kris-Etherton: Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA16802, USA.

Abstract

Fruit intake is associated with lower risk of cardiometabolic diseases. However, effects of dried fruits on cardiometabolic health are not well researched. We investigated the effect of daily dried fruit consumption compared with a carbohydrate-rich snack on cardiometabolic disease risk factors in adults with increased cardiometabolic risk. A two-period randomised crossover trial was conducted in adults (n 55) with elevated BMI and at least one additional risk factor for cardiometabolic disease to compare the effects of consuming 3/4 cup/d mixed dried fruits (plums, figs, dates and raisins) or an energy- and carbohydrate-matched control snack for 4 weeks. The primary outcome was LDL-cholesterol; secondary outcomes included other lipids and lipoproteins, glucose and insulin, C-reactive protein, blood pressure and vascular stiffness. Linear mixed models were used for data analysis. Lipid and lipoprotein concentrations did not differ between conditions; however, dried fruit increased LDL-cholesterol (0·10 mmol/l, 95 % CI 0·01, 0·20) compared with baseline. Compared with the control, dried fruit increased mean fasting glucose (0·08 mmol/l, 95 % CI 0·005, 0·16; P = 0·038). Vascular outcomes, fasting insulin and C-reactive protein did not differ between conditions. Mean weight changes did not differ (P = 0·55) but tended to increase after both conditions (dried fruit 0·3 kg, 95 % CI -0·09, 0·65; control 0·4 kg, 95 % CI 0·01, 0·75). Thus, short-term daily consumption of a large portion of mixed dried plums, figs, dates and raisins, without structured dietary guidance, did not improve cardiometabolic risk factors, compared with carbohydrate-rich snacks, in adults with increased baseline cardiometabolic risk.

Keywords

References

  1. BMJ Open. 2014 Nov 05;4(11):e005497 [PMID: 25377009]
  2. Br J Nutr. 2016 Apr;115(8):1406-14 [PMID: 26888153]
  3. Clin Chem. 1972 Jun;18(6):499-502 [PMID: 4337382]
  4. N Engl J Med. 1997 Apr 17;336(16):1117-24 [PMID: 9099655]
  5. J Am Diet Assoc. 2008 May;108(5):804-14 [PMID: 18442504]
  6. Nutr Res. 2008 May;28(5):304-8 [PMID: 19083424]
  7. Plant Foods Hum Nutr. 2013 Jun;68(2):145-8 [PMID: 23564595]
  8. Nutr Rev. 2020 Jul 1;78(7):532-545 [PMID: 31889199]
  9. Nutrients. 2018 Nov 28;10(12): [PMID: 30487459]
  10. Eur Heart J. 2017 Aug 21;38(32):2459-2472 [PMID: 28444290]
  11. Nutrients. 2017 Mar 11;9(3): [PMID: 28287476]
  12. Lipids Health Dis. 2008 Apr 16;7:14 [PMID: 18416823]
  13. JAMA. 2012 Oct 17;308(15):1545-54 [PMID: 23073951]
  14. Ann Nutr Metab. 2011;58(3):232-8 [PMID: 21811062]
  15. Eur J Epidemiol. 2017 May;32(5):363-375 [PMID: 28397016]
  16. Circulation. 2019 Jun 18;139(25):e1082-e1143 [PMID: 30586774]
  17. J Agric Food Chem. 2004 Jun 16;52(12):4026-37 [PMID: 15186133]
  18. Br J Nutr. 2019 Oct 14;122(7):723-733 [PMID: 31514758]
  19. Nutr Rev. 2015 Apr;73(4):216-35 [PMID: 26024545]
  20. Lancet. 2017 Sep 16;390(10100):1151-1210 [PMID: 28919116]
  21. J Acad Nutr Diet. 2013 Oct;113(10):1317-31 [PMID: 23871110]
  22. Trends Endocrinol Metab. 2011 Feb;22(2):60-5 [PMID: 21067942]
  23. J Nutr Sci. 2014 Jan 07;3:e1 [PMID: 25191601]
  24. J Nutr Biochem. 2016 Aug;34:73-82 [PMID: 27239754]
  25. J Agric Food Chem. 2009 Aug 12;57(15):6485-501 [PMID: 19580283]
  26. Phys Sportsmed. 2015 Feb;43(1):37-43 [PMID: 25609549]
  27. Nutr Res. 2019 May;65:89-98 [PMID: 30952505]
  28. Eur Heart J. 2018 Jul 7;39(26):2497-2505 [PMID: 29020416]
  29. Postgrad Med. 2014 Jan;126(1):37-43 [PMID: 24393750]
  30. Am J Clin Nutr. 2005 Jan;81(1 Suppl):230S-242S [PMID: 15640486]
  31. Int J Epidemiol. 2017 Jun 1;46(3):1029-1056 [PMID: 28338764]
  32. Nutrients. 2018 May 30;10(6): [PMID: 29848962]
  33. Crit Rev Food Sci Nutr. 2016 Jul 29;56 Suppl 1:S110-29 [PMID: 26191781]
  34. Prev Chronic Dis. 2013;10:E34 [PMID: 23489639]
  35. J Am Heart Assoc. 2015 Sep 10;4(9):e001700 [PMID: 26358358]
  36. Crit Rev Food Sci Nutr. 2018 May 24;58(8):1310-1329 [PMID: 27880063]
  37. J Agric Food Chem. 2008 Nov 12;56(21):9918-26 [PMID: 18937488]
  38. Food Nutr Res. 2017 Sep 24;61(1):1378567 [PMID: 29056890]
  39. Int J Food Sci Nutr. 2019 Sep;70(6):675-687 [PMID: 30810423]
  40. J Acad Nutr Diet. 2012 Aug;112(8):1158-68 [PMID: 22818725]
  41. Nutr Diabetes. 2018 Dec 11;8(1):59 [PMID: 30531821]
  42. Crit Rev Food Sci Nutr. 2019;59(7):1071-1090 [PMID: 29039970]
  43. Public Health Nutr. 2018 Jun;21(9):1636-1638 [PMID: 29587886]
  44. Am J Clin Nutr. 2012 Oct;96(4):727-34 [PMID: 22952180]
  45. Am J Clin Nutr. 1991 May;53(5):1259-65 [PMID: 1850578]
  46. Food Res Int. 2019 May;119:244-267 [PMID: 30884655]
  47. Nutr Rev. 2020 Feb 1;78(2):145-174 [PMID: 31532485]
  48. Diabetologia. 1985 Jul;28(7):412-9 [PMID: 3899825]
  49. Nutr Metab Cardiovasc Dis. 2015 Mar;25(3):253-66 [PMID: 25456155]
  50. Food Funct. 2016 Aug 10;7(8):3370-81 [PMID: 27406420]

Grants

  1. UL1 TR002014/NCATS NIH HHS

MeSH Term

Adult
Blood Glucose
Blood Pressure
C-Reactive Protein
Cardiometabolic Risk Factors
Cardiovascular Diseases
Cholesterol, LDL
Cross-Over Studies
Diet
Dietary Carbohydrates
Eating
Female
Food, Preserved
Fruit
Humans
Insulin
Linear Models
Lipids
Lipoproteins
Male
Middle Aged
Snacks
Vascular Stiffness

Chemicals

Blood Glucose
Cholesterol, LDL
Dietary Carbohydrates
Insulin
Lipids
Lipoproteins
C-Reactive Protein

Word Cloud

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