Mohammad Reza Salahshoor, Amir Abdolmaleki, Azita Faramarzi, Arash Ziapour, Shiva Roshankhah
CONTEXT: is an herbal with potent antioxidant and it has been shown to have beneficial effects during short-term administration. Myleran (MYL) is used for treatment of certain types of tumors. MYL produces free radicals and induces disturbance in sperm parameters.
AIMS: This study is designed to assess the effects of against damage to the male rats' reproductive features induced by MYL.
SUBJECTS AND METHODS: Sixty-four male Wistar rats were randomly assigned into eight groups: control group; MYL (10 mg/kg) group; groups (4.5, 9, and 18 mg/kg); and MYL (10 mg/kg) + groups (4.5, 9, and 18 mg/kg; separately). Treatments were administered daily intraperitoneal injection for 60 days. Total antioxidant capacity, sperm factors, malondialdehyde (MDA), testosterone, and germinal layer height were analyzed.
RESULTS: Whole variables of MYL group decreased signifcantly compared to the control group ( < 0.05) except MDA level (which increased). The and + MYL treatments in all doses increased all parameters significantly except MDA level (which decreased) compared to the MYL group ( < 0.05). No significant modifications were observed in all groups compared to the control group ( > 0.05).
CONCLUSIONS: reduces the poisonous properties of MYL on male reproductive factors.
