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Science translational medicine
06 24, 2020;12 (549):

Biology of antimicrobial resistance and approaches to combat it.

Sarah M Schrader, Julien Vaubourgeix, Carl Nathan
Author Information
  1. Sarah M Schrader: Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA. ORCID
  2. Julien Vaubourgeix: MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK. ORCID
  3. Carl Nathan: Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY 10065, USA. cnathan@med.cornell.edu. ORCID
PMID: 32581135 DOI: 10.1126/scitranslmed.aaz6992

Abstract

Insufficient development of new antibiotics and the rising resistance of bacteria to those that we have are putting the world at risk of losing the most widely curative class of medicines currently available. Preventing deaths from antimicrobial resistance (AMR) will require exploiting emerging knowledge not only about genetic AMR conferred by horizontal gene transfer or de novo mutations but also about phenotypic AMR, which lacks a stably heritable basis. This Review summarizes recent advances and continuing limitations in our understanding of AMR and suggests approaches for combating its clinical consequences, including identification of previously unexploited bacterial targets, new antimicrobial compounds, and improved combination drug regimens.

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Grants

  1. F30 AI140623/NIAID NIH HHS
  2. MR/P028225/1/Medical Research Council
  3. T32 GM007739/NIGMS NIH HHS
  4. U19 AI111143/NIAID NIH HHS

MeSH Term

Anti-Bacterial Agents
Anti-Infective Agents
Bacteria
Biology
Drug Resistance, Bacterial

Chemicals

Anti-Bacterial Agents
Anti-Infective Agents
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 21

Word Cloud

Created with Highcharts 10.0.0AMRresistanceantimicrobialnewapproachesInsufficientdevelopmentantibioticsrisingbacteriaputtingworldrisklosingwidelycurativeclassmedicinescurrentlyavailablePreventingdeathswillrequireexploitingemergingknowledgegeneticconferredhorizontalgenetransferdenovomutationsalsophenotypiclacksstablyheritablebasisReviewsummarizesrecentadvancescontinuinglimitationsunderstandingsuggestscombatingclinicalconsequencesincludingidentificationpreviouslyunexploitedbacterialtargetscompoundsimprovedcombinationdrugregimensBiologycombatit

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