Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification.
Richard A Parker, Christopher J Weir
Author Information
Richard A Parker: Edinburgh Clinical Trials Unit, Usher Institute, The University of Edinburgh, Edinburgh, UK. ORCID
Christopher J Weir: Edinburgh Clinical Trials Unit, Usher Institute, The University of Edinburgh, Edinburgh, UK. ORCID
There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position in simple multi-arm trials of distinct treatments.
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Case-Control Studies
Clinical Trials as Topic
Consensus
Data Interpretation, Statistical
Humans
Research Design
Risk Assessment
Treatment Outcome
Uncertainty
