Prevalence, risk factors and molecular epidemiology of carbapenem-resistant in patients from Zhejiang, China, 2008-2018.
Yanyan Hu, Congcong Liu, Zhangqi Shen, Hongwei Zhou, Junmin Cao, Shi Chen, Huoyang Lv, Mingming Zhou, Qiang Wang, Long Sun, Qiaoling Sun, Fupin Hu, Yang Wang, Rong Zhang
Author Information
Yanyan Hu: Clinical Microbiology Laboratory, 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Congcong Liu: Clinical Microbiology Laboratory, 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Zhangqi Shen: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Hongwei Zhou: Clinical Microbiology Laboratory, 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Junmin Cao: Department of Hospital Infection Control, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, People's Republic of China.
Shi Chen: Clinical Microbiology Laboratory, Hangzhou Third people's Hospital, Hangzhou, People's Republic of China.
Mingming Zhou: National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Qiang Wang: Clinical Microbiology Laboratory, 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Long Sun: Department of Clinical Laboratory, Hangzhou Maternity and Child Health Care Hospital, Hangzhou, People's Republic of China.
Qiaoling Sun: Clinical Microbiology Laboratory, 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Fupin Hu: Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.
Yang Wang: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Rong Zhang: Clinical Microbiology Laboratory, 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Carbapenem-resistant (CRKP) is emerging as a worldwide public health concern; however, the long-term molecular epidemiological surveillance of clinical CRKP in China is limited. We conducted a retrospective observational study (2008-2018) to assess the prevalence, susceptibility, risk factors and molecular epidemiology of clinical CRKP isolates. We found the prevalence of CRKP increased from 2.5%, 2008 to 15.8%, 2018. CRKP were significantly more frequent among hospitalized patients from ICU, and it was significantly more likely to be isolated from the capital city (Hangzhou) and the patients aged ≥60 years. Additionally, seasons and specimen types were associated with CRKP infections The main CRKP sequence type (ST) was ST11, and was the most prevalent gene variant. Together these data reveal an increasing incidence and resistance trends among CRKP, especially the ST11- -CRKP, in Zhejiang, during 2008-2018. Our findings are important for hospitals to limit its dissemination and optimize antibiotic administration.
