Muscle Glycogen Utilization during Exercise after Ingestion of Alcohol.
Harry A Smith, Aaron Hengist, Drusus Johnson Bonson, Jean-Philippe Walhin, Robert Jones, Kostas Tsintzas, Gregg H Afman, Javier T Gonzalez, James A Betts
Author Information
Harry A Smith: Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UNITED KINGDOM.
Aaron Hengist: Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UNITED KINGDOM.
Drusus Johnson Bonson: Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UNITED KINGDOM.
Jean-Philippe Walhin: Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UNITED KINGDOM.
Robert Jones: School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UNITED KINGDOM.
Kostas Tsintzas: School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UNITED KINGDOM.
Gregg H Afman: Department of Kinesiology, Westmont College, Santa Barbara, CA.
Javier T Gonzalez: Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UNITED KINGDOM.
James A Betts: Centre for Nutrition, Exercise and Metabolism, Department for Health, University of Bath, Bath, UNITED KINGDOM.
PURPOSE: Ingested ethanol (EtOH) is metabolized gastrically and hepatically, which may influence resting and exercise metabolism. Previous exercise studies have provided EtOH intravenously rather than orally, altering the metabolic effects of EtOH. No studies to date have investigated the effects of EtOH ingestion on systemic and peripheral (e.g., skeletal muscle) exercise metabolism. METHODS: Eight men (mean ± SD; age = 24 ± 5 yr, body mass = 76.7 ± 5.6 kg, height = 1.80 ± 0.04 m, V˙O2peak = 4.1 ± 0.2 L·min) performed two bouts of fasted cycling exercise at 55% V˙O2peak for 2 h, with (EtOH) and without (control) prior ingestion of EtOH 1 h and immediately before exercise (total dose = 0.1 g·kg lean body mass·h; 30.2 ± 1.1 g 40% ABV Vodka; fed in two equal boluses) in a randomized order, separated by 7-10 d. RESULTS: Muscle glycogen use during exercise was not different between conditions (mean [normalized 95% confidence interval]; EtOH, 229 [156-302] mmol·kg dm, vs control, 258 [185-331] mmol·kg dm; P = 0.67). Mean plasma glucose concentrations during exercise were similar (control, 5.26 [5.22-5.30], vs EtOH, 5.34 [5.30-5.38]; P = 0.06). EtOH ingestion resulted in similar plasma nonesterified fatty acid concentrations compared with rest (control, 0.43 [0.31-0.55] mmol·L, vs EtOH, 0.30 [0.21-0.40] mmol·L) and during exercise. Plasma lactate concentration was higher during the first 30 min of rest after EtOH consumption (mean concentration; control, 0.83 [0.77-0.90] mmol·L, vs EtOH, 1.00 [0.93-1.07] mmol·L), but the response during exercise was similar between conditions. CONCLUSIONS: Muscle glycogen utilization was similar during exercise with or without prior EtOH ingestion, reflected in similar total whole-body carbohydrate oxidation rates observed.
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