Effects of high-frequency, high-intensity transcutaneous electrical nerve stimulation versus intravenous opioids for pain relief after hysteroscopy: a randomized controlled study.

Birgitta Platon, Sven-Egron Thörn, Clas Mannheimer, Paulin Andréll
Author Information
  1. Birgitta Platon: Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
  2. Sven-Egron Thörn: Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  3. Clas Mannheimer: Multidisciplinary Pain Center Kungälv Hospital Kungälv and Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden.
  4. Paulin Andréll: Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Abstract

OBJECTIVE: To compare the time spent in the Post-Anesthesia Care Unit (PACU) and the pain-relieving effects of treatment with high-frequency, high-intensity transcutaneous electrical nerve stimulation (TENS) or intravenous (IV) opioids after hysteroscopy.
METHODS: All patients who postoperatively reported a visual analogue scale (VAS) pain score of ≥3 were included in the study. TENS treatment was given with a stimulus intensity between 40 and 60 mA for 1 minute and repeated once if there was insufficient pain relief. In the opioid group, a fractionated dose of 5 mg morphine was administered. If the patient reported insufficient pain relief after the assigned treatment, the patient was reassigned to the other treatment group.
RESULTS: Seventy-four women were randomized to TENS (n=38) or IV opioids (n=36) for treatment. Both groups reported significant pain relief after discharge from the PACU, with a decrease of VAS scores from 5.6 to 1.4 in the TENS group (P<0.001) and 5.1 to 1.3 in the opioid group (P<0.001). There were no significant differences between the groups. When only the responders in both groups, i.e., patients with VAS scores of <3 on respectively assigned treatments, were compared, the TENS responders (n=22) were found to have spent a significantly shorter time in the PACU (91 vs. 69 minutes, P=0.013) compared to the opioid responders (n=20).
CONCLUSION: Using TENS as first line of pain relief may reduce the need for postoperative opioids. In addition, TENS appears preferable as the first line of treatment due to its association with a shorter time spent in the PACU if the patient responds to the treatment.
TRIAL REGISTRATION: Västra Götalandsregionen Identifier: 211261.

Keywords

References

  1. Fertil Steril. 2003 Jun;79(6):1422-7 [PMID: 12798892]
  2. Cochrane Database Syst Rev. 2013 Sep 30;(9):CD005056 [PMID: 24085642]
  3. Obstet Gynecol. 2017 Feb;129(2):363-370 [PMID: 28079781]
  4. Lancet. 2006 May 13;367(9522):1618-25 [PMID: 16698416]
  5. Cochrane Database Syst Rev. 2002;(1):CD002123 [PMID: 11869624]
  6. Pain. 2010 Jan;148(1):114-9 [PMID: 19959293]
  7. Curr Opin Anaesthesiol. 2018 Jun;31(3):268-273 [PMID: 29474214]
  8. Pain. 1984 Jul;19(3):295-303 [PMID: 6089074]
  9. Aust N Z J Obstet Gynaecol. 2016 Feb;56(1):102-6 [PMID: 26817525]
  10. Am J Obstet Gynecol. 1994 Jan;170(1 Pt 1):123-9 [PMID: 8296814]
  11. Science. 1965 Nov 19;150(3699):971-9 [PMID: 5320816]
  12. Br J Anaesth. 2012 Feb;108(2):193-201 [PMID: 22250276]
  13. Saudi J Anaesth. 2018 Oct-Dec;12(4):618-625 [PMID: 30429746]
  14. Br J Obstet Gynaecol. 1999 Apr;106(4):356-9 [PMID: 10426243]
  15. Anesth Analg. 2017 Nov;125(5):1733-1740 [PMID: 29049117]
  16. Korean J Anesthesiol. 2018 Apr;71(2):149-156 [PMID: 29619788]
  17. Arch Gynecol Obstet. 2016 Jan;293(1):37-46 [PMID: 26253336]
  18. Arch Gynecol Obstet. 2012 Apr;285(4):1059-64 [PMID: 22009510]
  19. Pain. 1995 May;61(2):277-84 [PMID: 7659438]
  20. JAMA Surg. 2017 Jun 21;152(6):e170504 [PMID: 28403427]
  21. Intensive Care Med. 2000 Mar;26(3):275-85 [PMID: 10823383]
  22. Pain. 1996 Jan;64(1):123-8 [PMID: 8867254]
  23. Pain. 2010 Oct;151(1):215-9 [PMID: 20728275]
  24. Pain. 1979 Jun;6(3):305-27 [PMID: 460936]
  25. Int J Gynaecol Obstet. 1998 Mar;60(3):251-5 [PMID: 9544709]
  26. J Pain. 2011 Aug;12(8):929-35 [PMID: 21481649]
  27. Pain. 1986 Sep;26(3):291-300 [PMID: 3534690]

Grants

  1. ALFGBG-724711/ALF-agreement

Word Cloud

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