Khaled Habas: Faculty of Life Sciences, University of Bradford , West Yorkshire, UK.
Chioma Nganwuchu: Faculty of Life Sciences, University of Bradford , West Yorkshire, UK.
Fanila Shahzad: Faculty of Life Sciences, University of Bradford , West Yorkshire, UK.
Rajendran Gopalan: Faculty of Life Sciences, University of Bradford , West Yorkshire, UK.
Mainul Haque: Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia, (National Defence University of Malaysia) , Kuala Lumpur, Malaysia. ORCID
Sayeeda Rahman: School of Medicine, American University of Integrative Sciences , Bridgetown, Barbados, West Indies.
Anwarul Azim Majumder: Faculty of Medical Sciences, The University of the West Indies, Cave Hill Campus , Bridgetown, Barbados, West Indies. ORCID
Talat Nasim: Faculty of Life Sciences, University of Bradford , West Yorkshire, UK.
INTRODUCTION: Coronavirus disease 2019 (COVID-19) was first detected in China in December, 2019, and declared as a pandemic by the World Health Organization (WHO) on March 11, 2020. The current management of COVID-19 is based generally on supportive therapy and treatment to prevent respiratory failure. The effective option of antiviral therapy and vaccination are currently under evaluation and development. AREAS COVERED: A literature search was performed using PubMed between December 1, 2019-June 23, 2020. This review highlights the current state of knowledge on the viral replication and pathogenicity, diagnostic and therapeutic strategies, and management of COVID-19. This review will be of interest to scientists and clinicians and make a significant contribution toward development of vaccines and targeted therapies to contain the pandemic. EXPERT OPINION: The exit strategy for a path back to normal life is required, which should involve a multi-prong effort toward development of new treatment and a successful vaccine to protect public health worldwide and prevent future COVID-19 outbreaks. Therefore, the bench to bedside translational research as well as reverse translational works focusing bedside to bench is very important and would provide the foundation for the development of targeted drugs and vaccines for COVID-19 infections.
