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Frontiers in immunology
2020;11 1473.

The Hippo Pathway in Innate Anti-microbial Immunity and Anti-tumor Immunity.

Qian Zhang, Ruyuan Zhou, Pinglong Xu
Author Information
  1. Qian Zhang: MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China.
  2. Ruyuan Zhou: MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China.
  3. Pinglong Xu: MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China.
PMID: 32849504 DOI: 10.3389/fimmu.2020.01473

Abstract

The Hippo pathway responds to diverse environmental cues and plays key roles in cell fate determination, tissue homeostasis, and organ regeneration. Aberrant Hippo signaling, on the other hand, has frequently been implicated in diversified pathologies such as cancer and immune dysfunction. Here, we summarize the recent but rapid progress in understanding the involvement of the Hippo pathway in innate immunity, with a special focus on the intrinsic mechanisms and mutual interactions between Hippo-YAP signaling and the innate immune response and its physiological impacts on anti-microbial immunity and anti-tumor immunity. Moving forward, we believe that systematic investigations under the physiological setting are needed to draw a clearer picture of the actions of Hippo in innate immunity.

Keywords

Hippo-YAP signaling anti-microbial anti-tumor immunity antiviral immunity cGAS-STING innate immunity interferon nucleic acid sensing

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MeSH Term

Animals
Hippo Signaling Pathway
Homeostasis
Humans
Immunity, Innate
Infections
Neoplasms
Protein Serine-Threonine Kinases
Signal Transduction

Chemicals

Protein Serine-Threonine Kinases
Journal Article Research Support, Non-U.S. Gov't Review
Article has an altmetric score of 1

Word Cloud

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