Challenges and Opportunities in Animal Models of Gambling-like Behavior.

Cole Vonder Haar
Author Information
  1. Cole Vonder Haar: Injury and Recovery Laboratory.

Abstract

In the past several years, there has been an explosion of interest in animal models of risk-based decision-making, a fundamental process associated with gambling disorder. While early work focused on establishing various tasks for assaying decision-making, current studies are determining the (subtle and not-so-subtle) influence of cues in driving risky decisions to better understand problem gambling. In addition, these decision-making paradigms are now being used to investigate comorbid conditions such as substance dependence or brain injury and replicating observations from human patients. These animal models have now developed to a point where therapeutic interventions may be assessed for not just gambling disorder, but also a number of other conditions which engender risky decision-making.

Keywords

References

  1. Curr Top Behav Neurosci. 2016;28:93-120 [PMID: 27418069]
  2. Neuropsychopharmacology. 2019 Jan;44(2):274-280 [PMID: 29875447]
  3. Front Psychiatry. 2018 Oct 16;9:503 [PMID: 30386266]
  4. J Neurosci. 2012 Oct 31;32(44):15450-7 [PMID: 23115182]
  5. J Neurosci. 2018 Feb 21;38(8):1901-1914 [PMID: 29348192]
  6. Brain Res. 2019 Feb 1;1704:103-113 [PMID: 30296430]
  7. Sci Rep. 2017 Jul 26;7(1):6625 [PMID: 28747679]
  8. Behav Pharmacol. 2018 Dec;29(8):732-744 [PMID: 30376458]
  9. Behav Neurosci. 2016 Feb;130(1):50-61 [PMID: 26653713]
  10. Behav Processes. 2017 Dec;145:1-9 [PMID: 28939341]
  11. Sci Rep. 2017 Jul 18;7(1):5718 [PMID: 28720904]
  12. Psychol Methods. 2002 Mar;7(1):19-40 [PMID: 11928888]
  13. Addict Biol. 2017 Jul;22(4):991-1001 [PMID: 27002211]
  14. J Comp Psychol. 2019 Aug;133(3):301-312 [PMID: 30589294]
  15. Anim Cogn. 2019 Jan;22(1):81-87 [PMID: 30430348]
  16. Behav Brain Res. 2017 May 1;324:100-108 [PMID: 28212944]
  17. J Exp Psychol Anim Learn Cogn. 2016 Apr;42(2):141-62 [PMID: 26881899]
  18. Neuropsychopharmacology. 2018 Jan;43(2):313-324 [PMID: 28741626]
  19. Neuroscience. 2017 Feb 7;342:101-119 [PMID: 26297897]
  20. J Psychiatry Neurosci. 2017 Nov;42(6):404-413 [PMID: 28832319]
  21. Front Neurosci. 2011 Oct 10;5:109 [PMID: 22013406]
  22. J Neurosci. 2019 Mar 6;39(10):1842-1854 [PMID: 30626700]
  23. J Neurosci. 2016 Jan 20;36(3):785-94 [PMID: 26791209]
  24. Exp Clin Psychopharmacol. 2020 Feb;28(1):26-31 [PMID: 31070428]
  25. Psychopharmacology (Berl). 2019 Jun;236(6):1901-1915 [PMID: 30706098]
  26. Psychopharmacology (Berl). 2017 Mar;234(6):1017-1028 [PMID: 28160035]
  27. Psychopharmacology (Berl). 2017 Oct;234(20):3091-3104 [PMID: 28733811]
  28. J Nucl Med. 2018 Jun;59(6):952-959 [PMID: 29496988]
  29. Cognition. 1994 Apr-Jun;50(1-3):7-15 [PMID: 8039375]
  30. Psychopharmacology (Berl). 2017 Jul;234(14):2177-2196 [PMID: 28417164]
  31. Sci Rep. 2017 Jul 5;7(1):4680 [PMID: 28680108]
  32. Brain Inj. 2020;34(1):140-148 [PMID: 31532706]
  33. Addict Biol. 2020 May;25(3):e12738 [PMID: 30848014]
  34. Neuropsychology. 2004 Jan;18(1):152-62 [PMID: 14744198]
  35. Psychiatry Res. 2019 Feb;272:692-697 [PMID: 30832188]
  36. Soc Psychiatry Psychiatr Epidemiol. 2019 Apr;54(4):517-523 [PMID: 30232507]
  37. J Exp Anal Behav. 2017 Jan;107(1):136-150 [PMID: 28101923]
  38. Behav Processes. 2019 Feb;159:37-41 [PMID: 30529687]
  39. J Exp Psychol Anim Learn Cogn. 2017 Jul;43(3):262-279 [PMID: 29120214]
  40. Behav Brain Res. 2017 Mar 1;320:244-254 [PMID: 27993692]
  41. Pharmacol Biochem Behav. 2018 Aug;171:20-29 [PMID: 29782943]
  42. Behav Processes. 2019 May;162:104-111 [PMID: 30742885]

Grants

  1. P20 GM109098/NIGMS NIH HHS
  2. R01 NS110905/NINDS NIH HHS

Word Cloud

Created with Highcharts 10.0.0decision-makinggamblinganimalmodelsdisordercuesriskynowconditionsbraininjurypastseveralyearsexplosioninterestrisk-basedfundamentalprocessassociatedearlyworkfocusedestablishingvarioustasksassayingcurrentstudiesdeterminingsubtlenot-so-subtleinfluencedrivingdecisionsbetterunderstandproblemadditionparadigmsusedinvestigatecomorbidsubstancedependencereplicatingobservationshumanpatientsdevelopedpointtherapeuticinterventionsmayassessedjustalsonumberengenderChallengesOpportunitiesAnimalModelsGambling-likeBehaviorDecision-makingaddictionenvironment

Similar Articles

Cited By (1)