OpenLB
Open Library of Bioscience
Advanced Search
Access microbiology
2019;1 (1): e000006.

Cell wall inhibitors increase the accumulation of rifampicin in .

Matthew B McNeil, Somsundaram Chettiar, Divya Awasthi, Tanya Parish
Author Information
  1. Matthew B McNeil: TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA.
  2. Somsundaram Chettiar: TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA.
  3. Divya Awasthi: TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA.
  4. Tanya Parish: TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA. ORCID
PMID: 32974492 DOI: 10.1099/acmi.0.000006

Abstract

There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability.

Keywords

Mycobacterium tuberculosis mycobacteria permeability rifampicin tuberculosis

References

  1. Science. 2005 Jan 14;307(5707):223-7 [PMID: 15591164]
  2. Nat Chem Biol. 2012 Feb 19;8(4):334-41 [PMID: 22344175]
  3. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5198-207 [PMID: 27297488]
  4. Commun Integr Biol. 2009 May;2(3):215-8 [PMID: 19641733]
  5. Antimicrob Agents Chemother. 2017 Mar 24;61(4): [PMID: 28115355]
  6. J Appl Microbiol. 2000 May;88(5):784-90 [PMID: 10792538]
  7. J Med Chem. 2016 Jul 14;59(13):6232-47 [PMID: 27275668]
  8. J Antimicrob Chemother. 2008 May;61(5):1076-82 [PMID: 18310137]
  9. Science. 1994 Jan 14;263(5144):227-30 [PMID: 8284673]
  10. J Antimicrob Chemother. 2000 Feb;45(2):159-65 [PMID: 10660497]
  11. Sci Rep. 2016 Sep 28;6:34293 [PMID: 27678056]
  12. Cell. 2017 Jul 13;170(2):249-259.e25 [PMID: 28669536]
  13. PLoS One. 2013 Apr 04;8(4):e60531 [PMID: 23593234]
  14. Nat Rev Drug Discov. 2009 Feb;8(2):111-28 [PMID: 19180105]
  15. Nature. 2000 Jun 22;405(6789):962-6 [PMID: 10879539]
  16. J Antimicrob Chemother. 2006 Aug;58(2):332-7 [PMID: 16751637]
  17. Nat Chem Biol. 2013 Aug;9(8):499-506 [PMID: 23770708]
  18. Antimicrob Agents Chemother. 1995 Nov;39(11):2484-9 [PMID: 8585730]
Journal Article
Article has an altmetric score of 2

Word Cloud

Created with Highcharts 10.0.0rifampicintuberculosisaccumulationwallinhibitorsassociatedincreasedpermeabilityneednewcombinationregimensIdentifyingsynergisticdrugcombinationscanavoidtoxicsideeffectsreducetreatmenttimesUsingfluorescentconjugatedemonstratedsynergycellIncreasedalsocellularCellincreaseMycobacteriummycobacteria

Similar Articles

Cited By